IndraLab

Statements

Sirolimus decreases the amount of ATXN3. 5 / 5
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"CCI-779, a rapamycin ester (i.e., an analogue of rapamycin) reduces both mutant huntingtin and ataxin-3 levels, thereby attenuating toxicity in mouse models of HD and SCA3, respectively XREF_BIBR."
20188203
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"Administration of a rapamycin analogue, CCI-779, to a SCA3 mouse model with an expanded ataxin-3 containing 70 glutamines, reduced soluble levels of expanded ataxin-3, decreased the number of aggregates in brains, and ameloriated motor dysfunction."
21930185
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"Consistent with the Drosophila data, the rapamycin analogue CCI-779 reduces both mutant huntingtin and ataxin-3 levels and ameliorates toxicity in mouse models of HD and spinocerebellar ataxia type 3, respectively XREF_BIBR, XREF_BIBR."
23377551
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"Consistent with the Drosophila data, the rapamycin analogue CCI-779 reduces both mutant huntingtin and ataxin-3 levels, thereby attenuating toxicity in mouse models of HD and spinocerebellar ataxia type 3, respectively."
21095248
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"Rapamycin treatment of induced pluripotent stem cells derived from SCA3 patients has been reported to decrease polyQ expanded ataxin-3 levels whilst leaving wild-type ataxin-3 levels unchanged [10]."
36980234