IndraLab

Statements

PKC activates KCNMA1. 13 / 15
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"Phosphorylation of serine-695 by protein kinase C blocks BK channel activity, and phosphorylation of serine-1151 by protein kinase C enhances the BK channel response to activation by guanosine 3′,5′-monophosphate-dependent protein kinase [31]."
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"Moreover, elevated expression of PKCβ in diabetic mouse aortas promotes the BK channel β1 subunit downregulation by impairing AKT signaling [327]."
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"XREF_BIBR, XREF_BIBR PKA, PKG, and PKC also modulate BK channel activity indirectly by modulating the frequency of Ca 2+ sparks generated by sarcoplasmic reticulum ryanodine sensitive Ca 2+ -release channels."
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"Conversely, vasoconstrictors associated with protein kinase C (PKC) decrease the hyperpolarizing influence of BK channels by decreasing BK channel sensitivity to Ca 2+ (reducing STOC amplitude) and by reducing the occurrence of Ca 2+ sparks (reducing STOC frequency)."
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"XREF_BIBR, XREF_BIBR CAMP, PKC and H2S can also promote the opening of BK channel in rat PASMC."
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"Subsequebntly, 1 year later, Velázquez-Marrero et al (110) showed that the β4 subunit affects the way PKA and PKC modulate the BK channel activity in the presence of alcohol."
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"The enhanced Phe mediated vascular activity was linked to the altered PKC modulated BK channel functions."
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"PKC modulates the contraction of DSM and BK channel activity in non DSM cells; however, the cellular mechanism regulating the PKC-BK channel interaction in DSM remains unknown."
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"PKC blockers diminish ethanol potentiation of BK channel activity in GH4/C1 cells but have no effect on GH4 and C1-STREX cells."
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"Indeed, PKC blockers diminished ethanol potentiation of BK channel activity in GH4/C1 cells."
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"In support of this suggestion are demonstrations of protein kinase C inhibition of Slo1 K + channel inhibition in vascular smooth muscle, although protein kinase C activation of Slo1 K + channel has also been reported."
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"Finally, we show that Slo clusters on the surface of hair cells are also increased by increased PKC activity and may contribute to the increasing amounts of channel clusters on the surface of high-frequency hair cells."
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"Numerous common serine/threonine kinases, including PKA, PKG, and diacylgycerol/Ca -dependent protein kinase C (PKC) modulate BK channel activity, but the PKA phosphorylation is possibly the best-understood mechanism [45,46]."
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