IndraLab

Statements

TNFAIP3 activates IL6. 6 / 6
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"Thirdly, Tnfaip3 fl/fl CD19-Cre B cells produced more IL-6 than Tnfaip3 fl/+ CD19-Cre and Tnfaip3 +/+ CD19-Cre cells after treatment with LPS and CpG (XREF_FIG)."
20705491
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"Moreover, TNFAIP3 has been reported to control NF-kappa B activity and promote liver regeneration by activating the inflammatory IL-6/STAT3 signaling pathway."
34490085
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"At this time, very little information is available regarding the interaction of TNFAIP3 and STAT3 activation, and what is there appears disease and tissue dependent : in liver, TNFAIP3 activity results in increased STAT3 phosphorylation and IL-6 induction via inhibition of suppressor of cytokine signaling 3."
28791018
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"Rather, these mice express increased quantities of splenic IL-4 mRNA (data not shown), and Tnfaip3 fl/fl CD19-Cre B cells produced more IL-6 and expressed higher amounts of co-stimulatory molecules upon stimulation."
20705491
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"Both Tnfaip3 OTU and OTU and Tnfaip3 ZF4 and ZF4 cells produced elevated amounts of the NF-kappaB dependent IL-6 and A20 mRNAs within one hour of TNF stimulation, consistent with increased NF-kappaB signaling in these cells (XREF_FIG)."
23602765
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"Tnfaip3 OTU and OTU and Tnfaip3 ZF4 and ZF4 cells produced less of the NF-kappaB dependent mRNAs IL-6 and cellular inhibitor of apoptosis protein 2 (cIAP2), and exhibited less NF-kappaB signaling than Tnfaip3 -/- cells, suggesting that neither A20 's C103 motif nor its ZF4 motif are singly responsible for all of A20 's functions during TNF signaling (XREF_SUPPLEMENTARY)."
23602765