IndraLab

Statements

NLRP6 binds CYLD. 11 / 11
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"These results suggested that Cyld associates with NLRP6 during an inflammatory response."
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"These results suggested that Cyld associates with NLRP6 during an inflammatory response."
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"GST—Cyld but not GST alone precipitated His—NLRP6, confirming a direct Cyld—NLRP6 interaction ( xref )."
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"Cyld interaction with NLRP6 was specific, as Cyld did not associate with other members of the NLR family such as NLRP3 and NLRP12 ( xref , xref ), which are also expressed in the colon."
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"Further, to investigate the role of NLRP6 and Cyld interaction in regulating IL-18, we induced colitis in Nlrp6 −/− , Cyld −/− and Cyld −/− Nlrp6 −/− mice using C. rodentium ."
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"To determine whether this interaction occurs endogenously, we performed co-immunoprecipitation experiments with anti-Cyld and anti-NLRP6 using the colonic mucosal lysates of C. rodentium —infected mice, which showed an interaction between Cyld and NLRP6 ( xref )."
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"To determine whether this interaction occurs endogenously, we performed co-immunoprecipitation experiments with anti-Cyld and anti-NLRP6 using the colonic mucosal lysates of C. rodentium -- infected mice, which showed an interaction between Cyld and NLRP6 (XREF_FIG)."
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"Cyld binds to NLRP6."
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"Cyld binds to NLRP6."
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"Anti-Myc immunoprecipitated Flag—NLRP6 and anti-Flag immunoprecipitated Myc—Cyld, suggesting that Cyld and NLRP6 physically interact ( xref )."
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"To test whether the Cyld—NLRP6 interaction was direct, we performed pulldown assays using GST—Cyld and His—NLRP6."
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