IndraLab

Statements

USP15 deubiquitinates SQSTM1. 6 / 6
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ubibrowser
No evidence text available
signor
"SQSTM1 Is a Substrate for RNF26 and the DUB USP15. Catalytically competent RNF26 (light red) recruits SQSTM1 (blue) and mediates ubiquitin ligation (red), which serves to attract UBDs of specific vesicle-associated adaptors. Dissociation of the RNF26/SQSTM1 complex, promoted by the DUB USP15 (yellow), releases target vesicles for (4) fast transport into the cell periphery."
27368102
reach
"USP15 and USP17 promote lysosomal exocytosis of lysosomal proteins, including cathepsin D and LGMN, by deubiquitinating p62."
39389361
reach
"Similarly, USP15 can also deubiquitinate p62, opposing RFN26 and allowing vesicle release into the cell’s periphery (35)."
39389361
reach
"At one point, endosomes leave the cloud, which involves the deubiquitination of SQSTM1 and p62 by the deubiquitinating enzyme USP15, and start their fast bidirectional microtubule based journey in the periphery along microtubules and finally the cortical actin cytoskeleton before reaching the cell surface."
29900632
reach
"At one point, endosomes leave the cloud, which involves the deubiquitination of SQSTM1 and p62 by the deubiquitinating enzyme USP15, and start their fast bidirectional microtubule based journey in the periphery along microtubules and finally the cortical actin cytoskeleton before reaching the cell surface."
29900632