IndraLab

Statements

SP inhibits KCNH2. 2 / 2
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"SP decreased HERG currents in a concentration dependent manner (IC50 = 23.0 +/-1.5 micromol/L) and shifted the midpoint of the activation curve to more negative potentials (Vh = -13.1 +/-3.4 versus -18.9 +/-3.6 mV, P < 0.05) without modifying the activation and deactivation kinetics."
12591761
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"Both spironolactone (SP) and its main metabolite, canrenoic acid (CA), prolong cardiac action potential duration and decrease the Kv11.1 (HERG) current."
15980874