IndraLab
Statements
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"In our experiments, we used the high affinity BK channel blockers IbTX and PAX to investigate on the relationship between their blocking mechanisms and biological effects, such as cell cycle progression and the associated intracellular signaling, morphological changes, and cell proliferation."
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"Notwithstanding these results originating from whole carotid body preparations, or from the isolated type I cell in culture, it was observed, by other laboratories, that IbTX inhibition of maxiK channels of type I cells in vitro could, just like hypoxia, induce neurosecretion from type I cells maintained in clusters or in thin slice preparations of the carotid body, where even drug induced secretion from quiescent cells was often noted."
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"An alternative explanation is that IBTX disrupts the interaction of MaxiK with proteins, such as those involved in signal transduction (several potential candidates were recently identified as part of the MaxiK interactome) or translocation of MaxiK into the mitochondria (for example, through disrupting its interaction with Tom22) [XREF_BIBR, XREF_BIBR]."