IndraLab
Statements
reach
"This study presents : (i) to our knowledge, the first identification and characterization of an n-alkanol recognition site in a member of the voltage gated TM6 channel superfamily; (ii) structural insights on ethanol allosteric interactions with ligand gated ion channels; and (iii) a first step for designing agents that antagonize BK channel mediated alcohol actions without perturbing basal channel function."
reach
"Expression of WT HSLO rescued ethanol sensitivity for crawling speed but expression of HSLO (DM) did not (XREF_FIG; Kruskal-Wallis anova, genotype, H = 99.092, df = 5, P < 0.001; Dunn 's multiple comparison, slo-1 (null) vs. hslo (+) # 1 and slo-1 (null) vs. hslo (+) # 2, P < 0.05; slo-1 (null) vs. hslo (DM) # 1 and slo-1 (null) vs. hslo (DM) # 2; n = 16-122)."