IndraLab

Statements

KCNMA1 activates ethanol. 14 / 14
| 14
reach
"This study presents : (i) to our knowledge, the first identification and characterization of an n-alkanol recognition site in a member of the voltage gated TM6 channel superfamily; (ii) structural insights on ethanol allosteric interactions with ligand gated ion channels; and (iii) a first step for designing agents that antagonize BK channel mediated alcohol actions without perturbing basal channel function."
24927535
reach
"For example, microRNA regulation of slo encoded BK channel expression in rat magnocellular neurons has been shown to underlie a form of functional ethanol tolerance."
23371357
reach
"Ethanol Increases BK Channel Open Probability."
27827370
reach
"BK channel subunit composition modulates molecular tolerance to ethanol."
18537940
reach
"It has previously been demonstrated that BK channel beta subunits modulate the two components of ethanol tolerance."
19389201
reach
"Ethanol inhibition of BK transients was caused by a reduction in Ca (2+) spark frequency (-49%), a subsarcolemmal Ca (2+) signal that evokes the BK transients, and a direct inhibition of BK channel steady-state activity (-44%)."
15604147
reach
"For example, miR-9-dependent destabilization of the BK channel can mediate ethanol induced tolerance."
22141737
reach
"In some contexts, BK channel blockers may reduce the rewarding effects of alcohol, potentially curbing addiction."
40236633
reach
"In support of a central role for the BK receptor in ethanol sensitivity and tolerance, deletion of the BK channel gene blocks ethanol mediated behavioral responses and the development of tolerance."
22394481
reach
"Expression of WT HSLO rescued ethanol sensitivity for crawling speed but expression of HSLO (DM) did not (XREF_FIG; Kruskal-Wallis anova, genotype, H = 99.092, df = 5, P < 0.001; Dunn 's multiple comparison, slo-1 (null) vs. hslo (+) # 1 and slo-1 (null) vs. hslo (+) # 2, P < 0.05; slo-1 (null) vs. hslo (DM) # 1 and slo-1 (null) vs. hslo (DM) # 2; n = 16-122)."
26113050
reach
"Repeated exposure to EtOH increases BK channel expression or alters functionality in fruit flies and rodents."
40236633
reach
"Furthermore, flies with inducible SLO expression demonstrated faster recovery times and increased resistance to EtOH-induced sedation than control flies."
40236633
reach
"In this review, we discuss BK channels structure and function, and how they help us understand the various ways BK channel mediates alcohol 's effects on neuronal function and on behavior in the striatum."
20813247
reach
"Genetic alteration of BK channel function modulates acute behavioral tolerance in Drosophila and mice as well as the escalation of ethanol consumption during withdrawal periods in mice."
26113050