IndraLab

Statements

RPS6KB1 phosphorylates IRS1 on S307. 48 / 61
1 1 1 | 28 20 10
reach
"When mTORC1 is chronically activated following excessive glucose or branched chain amino acid consumption, the sustained simulation of downstream S6K1 increases IRS1 Ser307 phosphorylation."
32926928
reach
"S6K1 can further impair the phosphoinositide 3-kinase (PI3K)/ protein kinase B (AKT) signaling pathway by phosphorylating insulin receptor substrate 1 (IRS1) serine residues, including Ser-302/307, Se[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
38219809
sparser
"S6K1 phosphorylates IRS1 at S307 and S632 and inhibits insulin-induced Akt phosphorylation, making a negative feedback loop ( Um et al., 2004 )."
22391413
sparser
"We observed that S6K1-dependent phosphorylation of IRS1 on S307 and S1101 was diminished in SH-SY5Y cells treated with miR-200b and miR-200c."
29738527
sparser
"The insulin- and nutrient-stimulated kinase S6k1 phosphorylates Irs1 at Ser302, as well as other putatively inhibitory sites ( xref )."
20074531
reach
"When mTORC1 is chronically activated following excessive glucose or branched chain amino acid consumption, the sustained simulation of downstream S6K1 increases IRS1 Ser307 phosphorylation."
27826244
sparser
"IRS-1 S302 and S632 (S307 and S636, respectively, in humans) are directly phosphorylated by S6K1 and mTORC1, respectively ( Copps and White, 2012 )."
25813876
sparser
"IRS1 phosphorylation on S302 by S6K1 in TSC2-/- MEF in the same study is acutely reduced by rapamycin treatment along with IRS1 binding to PI3Kp85."
36005738
reach
"Recent studies revealed that insulin receptor substrate 1 (IRS1) S302, which is proximal to the IRS1 phosphotyrosine-binding (PTB) domain and contains an S6K1-recognition motif, is phosphorylated by S[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21185721
reach
"S6K1 phosphorylates insulin receptor substrate 1 (IRS-1) at Ser1101 and Ser302."
26926384
sparser
"In in vitro kinase assays, S6K1 directly phosphorylates S302 of mouse IRS-1 ( xref ), a site matching its preferred substrate recognition motif ( xref )."
15533996
reach
"When mTORC1 is activated, S6K1 could directly phosphorylate IRS1 (S307 and S636/S639) and promote its degradation, which subsequently blunts PI3K-AKT activation and its downstream effects such as glucose uptake, glycogen accumulation, etc. [2,3]."
30011848
reach
"IRS-1 S302 and S632 (S307 and S636, respectively, in humans) are directly phosphorylated by S6K1 and mTORC1, respectively (Copps and White, 2012)."
25813876
sparser
"However, studies on TSC2 −/− MEF demonstrate that TSC2 also potentiates this TSC1 inhibitory effect on S6K1 due to TSC2 antagonistic effect on IRS1 phosphorylation by S6K1 on S302 (and correspondent Serine on IRS2) as well as by repression of S6K1-mediated IRS1 (but not IRS2) gene expression [ xref ]."
36005738
reach
"In addition, when mTORC1 is activated, S6K1 could directly phosphorylate Insulin receptor substrate 1 (IRS1; S307 and S636 and S639) and promote its degradation, which subsequently blunts phosphoinositide 3-kinase (PI3K)-AKT activation and its downstream effects such as glucose uptake and glycogen accumulation."
33574765
sparser
"It has been reported that S6K1 can directly phosphorylate IRS1 at S307 and S636/S639, which abolishes the adaptor function of IRS1, leading to its insensitivity to upstream stimuli [ xref ]."
35879299
reach
"S6K1 can further impair the phosphoinositide 3-kinase (PI3K)/ protein kinase B (AKT) signaling pathway by phosphorylating insulin receptor substrate 1 (IRS1) serine residues, including Ser-302/307, Se[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
38219809
sparser
"CCR5 deficiency desensitizes insulin signaling by increasing p70 S6 kinase-mediated serine 302 phosphorylation of IRS-1."
27898058
sparser
"We did not observe elevated levels of components of mTOR/S6K pathway in case of single Pten or Lkb1 deletion in the bladder, however we show that Lkb1 deletion led to increased Ser302 phosphorylation of IRS-1 (equivalent to human Ser307 residue) by p70S6K ( xref )."
21283818
reach
"Western blot images showed that S6K1-dependent phosphorylation of IRS-1 on S307 and S1101, but not IRS-1 itself, were decreased in miR-200b- and miR-200c-transfected SH-SY5Y cells (Fig 5)."
29738527
sparser
"We report that, by several criteria, S6K1 does not phosphorylate IRS1 at serine 307 in response to insulin in intact human primary adipocytes: (i) The time-courses for phosphorylation of S6K1 and its phosphorylation of S6 are not compatible with the phosphorylation of IRS1 at serine 307; (ii) A dominant-negative construct of S6K1 inhibits the phosphorylation of S6, without effect on the phosphorylation of IRS1 at serine 307; (iii) The specific inhibitor of S6K1 PF-4708671 inhibits the phosphorylation of S6, without effect on phosphorylation of IRS1 at serine 307."
23565163
reach
"We observed that S6K1-dependent phosphorylation of IRS1 on S307 and S1101 was diminished in SH-SY5Y cells treated with miR-200b and miR-200c.The oAβ leads to additional generation of oAβ resulted from abnormal autophagosome accumulation via inhibition of mTOR pathway [17]."
29738527
reach
"The mTORC1-downstream p70 ribosomal protein S6 kinase (S6K1), which is activated by insulin, can phosphorylate IRS1 at serine 307 in vitro and is considered the physiological protein kinase."
23565163
reach
"The very different dynamics for phosphorylation of IRS1 at Ser307, on one hand, and of S6K1 at threonine 389 and S6 at serine 235/236, on the other, suggest that IRS1 is not phosphorylated at Ser307 by S6K1."
23565163
sparser
"Consistent with these observations it was found that S6K1 and S6K2 phosphorylate IRS-1 in vitro at S302, a site adjacent to its phosphotyrosine-binding (PTB) domain."
20932932
reach
"The non compatible time-courses, the selective effect of S6K1-DN, and the selective effect of the S6K1 inhibitor, each analyzes a very different aspect of signaling by S6K1 and each indicates non compatibility with S6K1 phosphorylating IRS1 at Ser307."
23565163
reach
"These include mammalian target of rapamycin (mTOR)-mediated phosphorylation of IRS1 serine 636 (Ser636) and serine 639 (Ser639), ribosomal S6 kinase 1 (S6K1)-mediated phosphorylation of IRS1 serine 307 [Ser307 (mouse serine 302) (Ser302)] and serine 1101, IkappaB kinase beta (IKKbeta) - and c-Jun N-terminal kinase (JNK)-mediated phosphorylation of IRS1 serine 312 [Ser312 (mouse Ser307)], and protein kinase zeta mediated phosphorylation of IRS1 serine 323 (mouse serine 318)."
18949383
sparser
"The very different dynamics for phosphorylation of IRS1 at Ser307, on one hand, and of S6K1 at threonine 389 and S6 at serine 235/236, on the other, suggest that IRS1 is not phosphorylated at Ser307 by S6K1."
23565163
sparser
"S6K1 phosphorylates Ser-307 of insulin receptor substrate-1 (IRS-1) and thereby activates an important feedback mechanism, which downregulates insulin signalling by inducing insulin resistance [ xref – xref ]."
22523661
reach
"P70S6K phosphorylates IRS-1 in serine 307 which leads to the uncoupling between IRS-1 and p85 (the regulatory subunit of PI3K) and therefore causing the lack of response of HepG2 to IGF-1."
23958494
reach
"Most likely, mTORC1 itself, rather than S6K1, phosphorylates IRS1 on Ser 307 to effect the inhibition of PI3K-Akt signaling, subsequently suppressing myogenic differentiation."
24068326
reach
"S6K1 phosphorylates Ser 307 of insulin receptor substrate-1 (IRS-1) and thereby activates an important feedback mechanism, which downregulates insulin signalling by inducing insulin resistance [XREF_BIBR - XREF_BIBR]."
22523661
reach
"However, studies on TSC2 MEF demonstrate that TSC2 also potentiates this TSC1 inhibitory effect on S6K1 due to TSC2 antagonistic effect on IRS1 phosphorylation by S6K1 on S302 (and correspondent Serine on IRS2) as well as by repression of S6K1-mediated IRS1 (but not IRS2) gene expression [88]."
36005738
sparser
"The non-compatible time-courses, the selective effect of S6K1-DN, and the selective effect of the S6K1 inhibitor, each analyzes a very different aspect of signaling by S6K1 and each indicates non-compatibility with S6K1 phosphorylating IRS1 at Ser307."
23565163
reach
"These studies revealed that IRS1 S302, which is proximal to the IRS1 phosphotyrosine-binding (PTB) domain and contains an S6K1-recognition motif, is phosphorylated by S6K1 [41,43] ."
17452018
reach
"First, it was found that S6K1 and S6K2 phosphorylate IRS-1 on serine 302, a site adjacent to its PTB domain."
23898460
reach
"S6K1 phosphorylates IRS1 at S307 and S632 and inhibits insulin-induced Akt phosphorylation, making a negative feedback loop ( Um et al., 2004 )."
22391413
reach
"It has been reported that S6K1 can directly phosphorylate IRS1 at S307 and S636/S639, which abolishes the adaptor function of IRS1, leading to its insensitivity to upstream stimuli [38]."
35879299
reach
"In in vitro kinase assays, S6K1 directly phosphorylates S302 of mouse IRS-1, a site matching its preferred substrate recognition motif."
15533996
reach
"The insulin- and nutrient stimulated kinase S6k1 phosphorylates Irs1 at Ser302, as well as other putatively inhibitory sites."
20074531
sparser
"Phosphorylation at Ser-302 of IRS-1 by S6K1 results in disruption of its interaction with insulin receptor and inhibits PI3K-mediated Akt activation ( xref ) ( xref )."
28342808
sparser
"However, other studies have revealed that S6K1-deficient mice on a high fat diet were more insulin sensitive, due to the loss of a negative feedback loop, whereas S6K1 phosphorylates insulin receptor substrate 1 (IRS1) on its insulin resistance phosphorylation site at S307 and S636/S639 in fat, liver and muscle to inhibit insulin signaling (Um et al, xref )."
39747664
reach
"The findings of the present study of diet-and obesity induced insulin resistance in murine models suggest that suppression of TSC1 by IKKbeta activates mTOR and S6K1, which in turn phosphorylate IRS1 at Ser636/639 and Ser307, thereby inhibiting IRS1 function)."
18949383
reach
"Consistent with these observations it was found that S6K1 and S6K2 phosphorylate IRS-1 in vitro at S302, a site adjacent to its phosphotyrosine binding (PTB) domain."
20932932
sparser
"A potential mechanism for crosstalk between adiponectin and insulin signalling is the adiponectin-mediated inhibition of p70 S6 kinase mediated serine phosphorylation of IRS1 at Ser302 and Ser636/639 [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24417944
sparser
"In addition, it has been reported that S6K1 phosphorylated IRS1 at S307 site to inhibit the binding of IRS1 to PI3K, which leads to impaired insulin signaling (Um et al, xref )."
39747664
reach
"Activation of the mTOR pathway functions as a feedback regulator of insulin action by increasing phosphorylation of IRS1 at Ser307 [pIRS (S307)] and Ser636/639 [pIRS (S636/639)] by S6K1 and mTOR, respectively."
18949383
sparser
"Western blot images showed that S6K1-dependent phosphorylation of IRS-1 on S307 and S1101, but not IRS-1 itself, were decreased in miR-200b- and miR-200c-transfected SH-SY5Y cells ( xref )."
29738527