IndraLab

Statements

STAMBP binds USP8. 8 / 8
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"Additionally, we conducted Co-IP experiments in NRK-52E cells to verify the binding situation, and the results demonstrated varying degrees of binding between Usp49, Stambp, Usp8, Usp9x, Usp33, Usp20, and Usp7 with TLR4."
38874156
sparser
"The interaction of the two endosomal DUBs, AMSH, and USP8 (UBPY in yeast), with a UIM-containing signal transducing adaptor molecule 2 (STAM2) enhances their deubiquitinating efficacy via substrate arrest [ xref , xref ]."
32512887
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"Both AMSH and Usp8 bind components of the endosomal sorting complex for transport (ESCRT) which are involved in targeting ubiquitinated cargo receptors for incorporation into intraluminal vesicles (IL[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23333852
sparser
"The competitive binding of AMSH and USP8 to ESCRT subunits, and the fact that they associate with both ESCRT-0 and –III, suggests that these DUBs may regulate cargo deubiquitination in complex ways."
21332354
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"The DUBs AMSH (associated molecule with the SH3 domain of STAM) XREF_BIBR and UBPY (ubiquitin isopeptidase Y/ubiquitin specific protease 8) XREF_BIBR, bind both the ESCRT-0 component STAM (signal transducing adaptor molecule) and ESCRT and III complex members XREF_BIBR, and are implicated in regulating EGFR sorting onto the degradative pathway."
24295852
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"The competitive binding of AMSH and USP8 to ESCRT subunits, and the fact that they associate with both ESCRT-0 and -III, suggests that these DUBs may regulate cargo deubiquitination in complex ways."
21332354
sparser
"AMSH and Usp8 bind with their PxxP motif to the non-canonical SH3-binding motif of ESCRT-0 protein STAM, and with their MIT (Microtubule Interacting and Transport)-domain to several CHMP proteins of t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23333852
sparser
"AMSH and USP8 can also interact with CHMP proteins that are components of the late ESCRT-III machinery xref , xref ."
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