IndraLab

Statements

USP8 binds STAMBP. 7 / 7
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sparser
"Both AMSH and Usp8 bind components of the endosomal sorting complex for transport (ESCRT) which are involved in targeting ubiquitinated cargo receptors for incorporation into intraluminal vesicles (IL[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23333852
sparser
"The interaction of the two endosomal DUBs, AMSH, and USP8 (UBPY in yeast), with a UIM-containing signal transducing adaptor molecule 2 (STAM2) enhances their deubiquitinating efficacy via substrate arrest [ xref , xref ]."
32512887
reach
"The DUBs AMSH (associated molecule with the SH3 domain of STAM) XREF_BIBR and UBPY (ubiquitin isopeptidase Y/ubiquitin specific protease 8) XREF_BIBR, bind both the ESCRT-0 component STAM (signal transducing adaptor molecule) and ESCRT and III complex members XREF_BIBR, and are implicated in regulating EGFR sorting onto the degradative pathway."
24295852
sparser
"AMSH and USP8 can also interact with CHMP proteins that are components of the late ESCRT-III machinery xref , xref ."
26918171
reach
"The competitive binding of AMSH and USP8 to ESCRT subunits, and the fact that they associate with both ESCRT-0 and -III, suggests that these DUBs may regulate cargo deubiquitination in complex ways."
21332354
sparser
"AMSH and Usp8 bind with their PxxP motif to the non-canonical SH3-binding motif of ESCRT-0 protein STAM, and with their MIT (Microtubule Interacting and Transport)-domain to several CHMP proteins of t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23333852
sparser
"The competitive binding of AMSH and USP8 to ESCRT subunits, and the fact that they associate with both ESCRT-0 and –III, suggests that these DUBs may regulate cargo deubiquitination in complex ways."
21332354