IndraLab

"Further CHIT1 interacts with TGF-β1 to augment fibroblast TGF-β receptor 1 and 2 expression and TGF-β-induced signaling. xref As an effector molecule of macrophage differentiation and activation, the role of CHIT1 is getting more attention as a modifier of tissue fibrosis or airway remodeling in addition to its role in innate immune response. xref , xref Since ILD and COPD are representative chronic lung diseases resulting from abnormal injury and tissue repair responses, the role and effects of CHIT1 in the development of these diseases are of great interest to understand the pathogenic mechanism of these diseases."