IndraLab

Statements

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"Overexpression of UCHL1 has been found to induce apoptosis in MCF-7 cells XREF_BIBR."
22279545
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"In summary, the present data provide evidence for the first time that UCH-L1 induces apoptosis in cultured breast cancer cells in vitro and the apoptotic effect is possibly through the PI3K and Akt pathway."
18949367
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"Uchl1 (-/-) mice had increased ER stress and beta cell apoptosis."
22038515
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"In mice, transgenic over-expression of UCH-L1 in spermatogonia causes a block during spermatogenesis at an early stage (pachytene) of meiosis and increased apoptosis of primary spermatocytes."
19388011
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"In breast cancer, ectopic expression of UCHL1 is able to induce apoptosis by stabilizing p53."
24155778
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"The results suggest that the proinflammatory cytokines upregulate UCHL1, which in turn promotes MSC apoptosis via Bcl-2-regulated activation of caspase 3."
29686406
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"UCHL1 induced G0/G1cell cycle arrest and apoptosis of breast tumor cells."
22279545
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"The results indicated that the process of apoptosis triggered by UCH-L1 is, at least in part, probably through Phosphoinositide 3-kinase (PI3K) / Akt signal pathway."
18949367
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"Our results showed that UCHL1 upregulation by VER enhanced the reversal effect of VER on chemo-resistance of HCC and promoted cell apoptosis."
29627846
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"For instance, Ubiquitin carboxyl-terminal hydrolase L1 (UCHL1), located on chromosome 4p14, can induce apoptosis through the intrinsic, caspase dependent pathway XREF_BIBR."
22572016
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"We showed that knockdown of UCHL1 in ovarian cancer cells promoted cell proliferation by inducing S phase cell cycle and reduced apoptosis."
24155778
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"Loss of UCH-L1 decreased the rate of apoptosis in the first round of spermatogenesis and increased the numbers of premeiotic germ cells in immature mice, but spermatogenesis was partially impaired with significant reduction of spermatogonia and primary spermatocytes which mainly go to apoptosis in adult mice."
19388011
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"These results suggest that UCHL1 is mediator of apoptosis and targeting UCHL1 might be of great potential to overcome cisplatin resistance in ovarian cancer."
24155778
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"Downregulation of UCH-L1 expression and activity in beta cells induces ER stress and apoptosis [XREF_BIBR]."
21915177
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"Studies showed that UCHL1 could induce apoptosis by stabilizing p53 in breast and hepatocellular carcinoma XREF_BIBR, XREF_BIBR, and promote ovarian cancer cell apoptosis associated with Bcl-2 family proteins regulated caspase activation 37."
29686406
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"However, over-expression of the UCH-L1 also induces germ cell apoptosis and inhibits spermatogenesis, leading to male sterility [XREF_BIBR]."
24189580
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"Our findings initiated future research for the rediscovery of MSCs, cancers/tumours and the UCHL1-induced apoptosis."
35865633
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"To explore the mechanisms of how reduced expression of UCHL1 promotes cell proliferation, reduces apoptosis and confers cisplatin resistance, we performed a microarray analysis to identify different genes regulated by UCHL1-knockdown."
24155778
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"This observation is consistent with a recent report that the over-expression of UCH-L1 induces testicular germ cell apoptosis in UCH-L1 transgenic mice."
18949367
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"UCH-L1 downregulation enhances ER stress induced beta-cell apoptosis, and UCH-L1 deficiency was observed in beta-cells of individuals with T2DM."
23349537
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"3.2 Reduced expression of UCHL1 in A2780 and IGROV1 reduced cell apoptosis but increases cell proliferation."
24155778
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"Interestingly, Drosophila genetic studies have shown that increased UCH-L1 levels in the eye imaginal discs induces caspase dependent apoptosis, resulting in a rough eye phenotype [XREF_BIBR]."
25403879
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"The ubiquitin peptidase UCHL1 induces G0/G1 cell cycle arrest and apoptosis through stabilizing p53 and is frequently silenced in breast cancer."
22279545
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"Loss of UCHL1, a deubiquitating enzyme responsible for regenerating monoubiquitin from the ubiquitin protein complex, decreased the rate of apoptosis in the first round of spermatogenesis and increased the numbers of premeiotic germ cells in immature mice [XREF_BIBR], whereas asymmetric distribution of UCHL1 in spermatogonia is associated with maintenance and differentiation of spermatogonial stem cells [XREF_BIBR]."
24950741
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"Upregulation of UCHL1 enhanced the reversal effect of VER on chemo-resistance to ADM and promoted cell apoptosis."
29627846
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"UCHL1 can induce apoptosis of tumor cells and is involved in various cancers XREF_BIBR - XREF_BIBR."
29686406
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"These data suggest that UCHL1 inhibition suppresses MSC apoptosis induced by proinflammatory cytokines via upregulation of Bcl-2."
29686406
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"To this end, we investigated whether UCHL1 regulated proinflammatory cytokines induced MSC apoptosis."
29686406
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"Further studies are needed to elucidate the mechanism of UCH-L1 induced apoptosis in detail."
18949367
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"UCHL1 also induced G0/G1 cell-cycle arrest and apoptosis of breast tumour cells, an activity that requires its catalytic activity and depends on the accumulation of p53 [140]."
23712866
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"It appears that UCHL-1 mediated apoptosis through stabilizing p53 might play a role in neuronal cell death in obese rat."
24949983
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"Further analysis of the embryonic MSCs revealed that: 1) proinflammatory cytokines and related genes TNF , TNFSF13B , TNFRSF12A , TNFAIP6 , and C1QTNF6 are significantly involved in the MSC-induced immune responses in cavernous hemangiomas; 2) UCHL1 is up-regulated in the embryonic MSC apoptosis induced by proinflammatory cytokines; 3) the UCHL1-induced apoptosis of MSCs may play an important role in the MSC-induced immune responses in cavernous hemangiomas; and 4) UCHL1 can be used as a marker gene to detect embryonic MSCs at different apoptosis stages."
35865633
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"Overexpression of UCHL1 genes promoted apoptosis in cells treated with VER+ADM."
29627846
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"To clarify the mechanism underling our observations in MCF7 and MCF7 and Adr cells, the expression of Akt and phospho-IkappaB-alpha was further investigated and results demonstrated that UCH-L1 induced apoptosis in breast cancer cells, possibly through the PI3K and Akt pathway."
18949367
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"UCHL1 also induced G0/G1 cell-cycle arrest and apoptosis of breast tumour cells, an activity that requires its catalytic activity and depends on the accumulation of p53 [XREF_BIBR]."
23712866
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"To obtain clues to the mechanism by which elevated expression of UCH-L1 induces apoptosis in MCF7 cells, lysates from UCH-L1 over-expressing MCF7 cells and negative controls were prepared and Western blot was carried out."
18949367
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"Jin et al. disclosed that the inhibition of UCHL1 promoted cell proliferation by increasing cells in S-phase and that the knockdown of UCHL1 reduced cell apoptosis and contributed to cisplatin resistance [63]."
31240215
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"Using 3-(4,5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay, Western blot, Hoechst 33258 staining assay and flow cytometry, we found that over-expression of UCH-L1 in MCF7 cells induced apoptosis."
18949367
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"Yet in our study, no significant alteration of p53 was found, suggesting UCHL1 mediated apoptosis in other ways rather than by regulating p53."
24155778
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"CONCLUSIONS Upregulation of UCHL1 enhanced the reversal effect of VER on chemo-resistance to ADM and promoted cell apoptosis."
29627846
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"Ectopic UCHL1 expression in breast tumor cells suppresses cell growth and induces G0/G1 arrest and apoptosis through p53 signaling due to its DUB activity [39]."
27260470
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"In both reproductive organs and nervous tissue, UCH-L1 promotes apoptosis."
21878121
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"UCHL1 has been observed to be epigenetically regulated in other cancers, and is believed to induce G0/G1 cell cycle arrest and apoptosis by stabilization of p53."
23894057
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"Downregulation of UCH-L1 expression and activity in beta-cells induces ER stress and apoptosis."
20980462
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"These data suggest that overexpression of UCH-L1 affects spermatogenesis during meiosis and, in particular, induces apoptosis in primary spermatocytes."
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"Contradictorily, UCHL1 has recently been shown to induce G0/G1 cell cycle arrest and apoptosis by stabilizing p53 and has also been shown to be frequently silenced in primary breast tumors, but not in[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"UCH-L1 siRNA is able to inhibit the proliferation of lung adenocarcinoma cell lines H157 and induce the apoptosis."
20677552
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"In addition, UCHL1 overexpression enhanced cell viability and promoted oxidative damage, apoptosis and senescence in H 2 O 2 -induced HEI-OC1 cells."
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