IndraLab

Statements

KCNG1 activates NFkappaB. 31 / 31
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"Despite this fact, alteration of these residues in K13 results in a mutant K13 that no longer activates NF-κB ( xref )."
22301546
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"To study the role of TAK1 in K13-induced NF-κB activation, we took advantage of murine embryonic fibroblast (MEFs) cells deficient in this protein."
22590573
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"In addition, TRAF3 has been reported to be required for K13-induced NF-kappaB and JNK activation."
17597077
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"Selective inhibitors of the IKK1 kinase activity may have a role in the treatment of disorders caused by abnormal NF-kappaB activation by HHV8 vFLIP K13."
14561765
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"Furthermore, endogenously expressed TRAF2 and TRAF3 do not interact with K13 and play no role in K13-induced NF-kappaB activation or its interaction with the IKK complex."
17597077
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"The stimulatory effect of 4OHT on G 1 to S phase transition was blocked by treatment with Bay-11-7082, thereby confirming the role of K13-induced NF-κB activation in this process ( xref )."
22624040
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"The K13-TRAF2 interaction is believed to be essential for the recruitment of K13 to the I-kappaB kinase (IKK) complex and for K13-induced NF-kappaB and JNK activation."
17597077
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"Furthermore, linear polyubiquitination of NEMO is not required for K13-induced NF-κB activation."
22590573
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"Selective NF-kappaB activation by K13 might represent a novel strategy employed by the virus to promote latency."
17597077
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"Taken collectively with previous studies, the above results confirm that TAK1 is not required for K13-induced NF-κB activation."
22590573
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"HOIL-1 is not Essential for K13-induced NF-κB Activation."
22590573
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"Biochemical studies have revealed some insights into the molecular mechanisms that control NF-κB activation by K13 and K15."
27538487
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"We used HOIL-1 -null MEFs to test the involvement of LUBAC-induced linear polyubiquitination in K13-induced NF-κB activation."
22590573
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"Sharpin is not Essential for K13-induced NF-κB Activation."
22590573
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"Ectopic expression of K13 failed to induce nuclear p65/RelA DNA binding activity in theNEMO −/Y MEFs reconstituted with an empty vector, but resulted in approximately 3 fold increase in the nuclear p65/RelA DNA binding activity in those reconstituted with the wild-type NEMO, thereby confirming that NEMO is required for K13-induced NF-κB activation ( xref )."
22590573
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"Thus, binding of NEMO to linear polyubiquitin chain is not required for K13-induced NF-κB activation."
22590573
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"As another independent test to rule out the involvement of linear Ub chains in K13-induced NF-κB activation, we tested the ability of CYLD to block K13-induced NF-κB-Luc reporter activity."
22590573
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"The studies in the preceding section clearly demonstrate that TAK1, TRAF6 and linear polyubiquitination of NEMO are not involved in K13-induced NF-κB activation."
22590573
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"K13-induced NF-κB activation has been reported to play an essential role in promoting the survival of latently-infected PEL cells by up-regulating the expression of anti-apoptotic proteins xref ."
17957251
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"In this report, we have excluded the involvement of TRAF6, which has been implicated in NF-κB activation during signaling emanating from IL-1 and Toll like receptors xref , xref , in K13-induced NF-κB activation."
22590573
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"To confirm the lack of involvement of linear polyubiquitination in K13-induced NF-κB activation, we took advantage of cells that are deficient in two essential components of LUBAC, an enzyme complex required for linear polyubiquitination."
22590573
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"Our results withHOIL-1 − / − and cpdm MEFs, rule out the requirement of LUBAC-induced linear polyubiquitination in K13-induced NF-κB activation."
22590573
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"In this study, we have investigated the role of TRAF6, TAK1 and LUBAC in K13-induced NF-κB activation."
22590573
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"The lack of requirement of linear polyubiquitination in K13-induced NF-κB activation was further supported by our results showing that CYLD, a deubiquitylating enzyme that can cleave linear ubiquitin chains, cannot block K13-induced NF-κB activity."
22590573
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"Interestingly, a F312A mutation in human NEMO, which corresponds to the F305A mutation in mouse NEMO tested in this study, was shown to be defective in binding to Lys63-linked ubiqutin chains xref , which suggests that K13 activates NF-κB independent of Lys63-linked chains as well."
22590573
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"Based on the lack of involvement of TRAF6, TAK1 and LUBAC in K13-induced NF-κB activation, we support a model according to which the interaction between K13 and NEMO is direct and is not mediated via the TRAF family members or the linear ubiquitin chains."
22590573
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"Therefore, we believe that rather than blocking NF-κB pathway globally, the ideal agent for the treatment of KSHV-associated lymphoproliferative disorders should selectively block K13-induced NF-κB activation."
22590573
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"Thus, K13 activates NF-κB via a mechanism distinct from that utilized by inflammatory cytokines."
22590573
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"TRAF6 is not Required for K13-induced NF-κB Activation."
22590573
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"As shown in xref , treatment with 4OHT resulted in equivalent upregulation of A20 in theTRAF6 +/+ andTRAF6 −/− ,which argues against the involvement of TRAF6 in K13-induced NF-κB activation."
22590573
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"TAK1 is not Required for K13-induced NF-κB Activation."
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