IndraLab

Statements

reach
"Overall, these data support a model for LRMP regulation of HCN4 where LRMP interacts with the HCN4 N-terminus to allosterically disrupt cAMP signal transduction between the C-linker, N-terminus, and S4-S5 linker (Porro et al., 2019; Wang et al., 2020b)."
37693562
reach
"Overall, these data support a model for LRMP regulation of HCN4 where LRMP interacts with the HCN4 N-terminus to allosterically disrupt cAMP signal transduction between the C-linker, N-terminus, and S4-S5 linker (Porro et al., 2019; Wang et al., 2020a)."
38652113
reach
"While our testing was limited to the subsaturating endogenous level of cAMP, we found no evidence to suggest that the HCN4 TM-replacement disrupts the cAMP dependent V 1/2 shift."
32146488
reach
"Because HCN1 is minimally sensitive to cAMP and has a more positive V 1/2 than HCN4, it is conceivable that a relative decrease in HCN1 and increase in HCN4 expression in aged SAMs could contribute to the hyperpolarizing shift in V 1/2 and increased cAMP response."
28057842
reach
"In the specific case of LRMP regulation of HCN4 channels, our data identify unique features of HCN4 that render its cAMP sensitivity particularly malleable, and thus could contribute to its unique function in the sinoatrial node of the heart.Although LRMP prevents the cAMP-dependent shift in HCN4 activation, LRMP does not act by preventing cAMP from binding to the channel."
37693562
reach
"In the specific case of LRMP regulation of HCN4 channels, our data identify unique features of HCN4 that render its cAMP sensitivity particularly malleable, and thus could contribute to its unique function in the sinoatrial node of the heart.Although LRMP prevents the cAMP-dependent shift in HCN4 activation, LRMP does not act by preventing cAMP from binding to the channel."
38652113