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ERK phosphorylates STAT3 on tyrosine. 9 / 11
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"Interestingly, serine phosphorylation of STAT3 by ERK has been reported to negatively modulate STAT3 tyrosine phosphorylation and activity [XREF_BIBR, XREF_BIBR], while other studies implicate the MEK and ERK cascade in positively mediating STAT3 activity [XREF_BIBR - XREF_BIBR]."
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"Although previous studies clearly demonstrated serine phosphorylation of STAT3 regulates ERK, the current results indicate that ERK may also phosphorylate tyrosine on STAT3."
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"Furthermore, our study reveals that PDGF-BB- and bFGF induced proliferation does not affect the osteogenic differentiation potential of hBMMSCs.All of the three GFs activated the hBMMSC ERK1/2 pathway[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Furthermore, as Gkouveris et al. indicated that ERK suppressed STAT3 tyrosine phosphorylation, induced by Src or Jak-2 [17], CB-PIC activated phosphorylation of ERK in HepG2 and Huh7 cells (Figure 4f)."
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"These results suggest that JAK2 and ERK may mediate tyrosine and serine phosphorylation of STAT3 induced by histamine, respectively, and that both phosphorylations may be required for the activation o[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"ERK1/2 specifically phosphorylates STAT3 at serine 727, which negatively modulates STAT3 tyrosine phosphorylation [XREF_BIBR]."
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"Recently, C5a was also demonstrated to induce STAT3 tyrosine phosphorylation (by a Jak-2-dependent mechanism) and STAT3 serine phosphorylation by an (ERK MAPK-dependent mechanism) in erythroleukemia c[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Furthermore, PDGF-BB-induced STAT3 tyrosine and serine phosphorylation in hBMMSCs are directly mediated by JAK2 and ERK1/2, respectively."
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"Jain et al. reported that STAT3 serine phosphorylation (S727) by ERK negatively regulates the tyrosine phosphorylation of STAT3 (Y705) [39] ."
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