IndraLab

Statements

UCHL5 inhibits Neoplasms. 5 / 5
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"As shown in Figures 7A–C, UCHL5 silence obviously repressed the size, volume, and weight of the xenograft tumors in the nude mice."
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"In our study, UCHL5 downregulation significantly suppressed both tumor growth in vivo and cell proliferation and migration in vitro."
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"Interestingly, b-AP15, a dual inhibitor of Usp14 and Uch37, was shown to prevent protein degradation and inhibit tumor progression in acute myeloid leukemia models [222]."
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"Notably, we found that the increase of UCHL5 expression in renal cancer cells decreases the antigen processing and presentation of RCC tumor-infiltrating B cells."
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"We also found that UCHL5 downregulation significantly suppressed both tumor growth in vivo and cell proliferation and migration in vitro."
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