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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

USP6 increases the amount of MBD3. 2 / 2

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"Thus, the intronic TRE2 in the MBD3 gene is bound by TR in premetamorphic tadpole intestine and likely mediate the activation of MBD3 expression by T3 via histone modification during metamorphosis."

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"To determine if the intronic TRE2 can mediate the transcriptional regulation of Xenopus tropicalis MBD3 expression by T3 in vivo, we cloned a genomic MBD3 fragment encompassing 1 kb upstream of the predicted transcription start site, exon 1 (276bp) and a part of intron 1 that included the putative TRE2 (265bp), upstream of the coding region of firefly luciferase gene in a reporter construct (Figure 4A)."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...