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USP37 leads to the deubiquitination of CDKN1B. 3 / 3
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"Constitutive expression of USP37 promotes p27 deubiquitination in medulloblastoma cells, whereas a catalytically dead USP37 mutant is unable to stabilize p27.Dobson et al. further explored the molecular basis of REST-induced USP37 downregulation and found that USP37 supresses medulloblastoma tumor growth in an orthotopic mouse model by modulating its downstream targets [87]."
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"Ectopically expressed wild-type <span class="match term0">USP37</span> formed a complex with <span class="match term1">p27</span>, promoted its deubiquitination and stabilization and blocked cell proliferation."
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"For example, USP37 promoted deubiquitination and stabilization of p27 and blocked medulloblastoma cell proliferation [ 18 ]."
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