IndraLab

Statements

CCND1 binds CCND1 and CDK4. 3 / 3
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"Consistent with previous reports, both cyclin D1a and cyclin D1b effectively interact with CDK4 (Lu et al , xref ) (Supplementary Fig xref )."
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"In many cell types, transcription of CCND1 and cyclin D1 assembly with CDK4 each depend on activation of a RAS-dependent kinase cascade that relies on the sequential activities of RAF1, MEK1 and MEK2, and ERKs ( xref - xref )."
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"Immunoprecipitation analysis revealed that cyclin D1a and cyclin D1-T286A could bind to cyclin-dependent kinase 4 (CDK4) but cyclin D1b has lost its capacity to associate with CDK4."
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