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IGF1R phosphorylates IRS1. 63 / 64
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rlimsp
"Once stimulated, the tyrosine kinase activity of IGF-1R leads to its autophosphorylation as well as the phosphorylation of a number of intracellular proteins, such as IRS-1, Shc and Gab1."
17129375
reach
"In the absence of IGF-I stimulation, or if mutated IGF-IR fails to phosphorylate IRS-1, localization of Rad51 to the sites of damaged DNA is diminished."
14559999
rlimsp
"In the absence of IGF-I stimulation, or if mutated IGF-IR fails to phosphorylate IRS-1, localization of Rad51 to the sites of damaged DNA is diminished."
14559999
sparser
"Following IRS1 activation, IGF1R phosphorylates IRS1 leading to its ubiquitination by FBXO40 and its degradation by the 26S proteasome, in cultured myotube and in mice [ xref , xref ]."
33466753
sparser
"Activated PP1 is sufficient to dephosphorylate at least four IRS1 Ser residues, Ser 318 , Ser 346 , Ser 612 , and Ser 789 , and promotes IRS1 YXXM phosphorylation by the IGF1R to activate the PI3K/AKT cascade."
27856640
trips
"In the absence of IGF-I stimulation, or if mutated IGF-IR fails to phosphorylate IRS-1, localization of Rad51 to the sites of damaged DNA is diminished."
14559999
reach
"In prostate cancer cells, co-inhibition of epidermal growth factor receptor and IGF-1R reduced phosphorylation of IRS-1 and its interaction with RAD51, suppressing HR and increasing radio-sensitivity [XREF_BIBR]."
26510816
signor
"Binding of IGF1 to its receptor leads to activation of its intrinsic tyrosine kinase and autophosphorylation, thus generating docking sites for insulin receptor substrate (IRS), which is also phosphorylated by the IGF1 receptor."
21798082
sparser
"One pathway involves IRS-1, which becomes tyrosine phosphorylated by IGF-IR and binds the Grb2/Sos complex through the SH2 domain of Grb2."
12837295
sparser
"Both IGF-I and IGF-II bind the tyrosine kinase receptor IGF1R, which in turn phosphorylates the insulin receptor substrates IRS-1 and IRS-2."
19261630
rlimsp
"Interestingly, autophosphorylation of the IGF-IR and phosphorylation of the downstream substrate, insulin receptor substrate-1 (IRS-1), was not inhibited in doxycycline/IGF-I treated cells, suggesting the possibility that activation of downstream substrates other than the IRS-1 may be critical for optimal cell proliferation."
14709803
reach
"In particular they act as competitive inhibitors of IGF-IR, promote inhibitory phosphorylation and degradation of IRS1 and IRS2 leading to the elimination of IRS1/2 and finally to cell death 27."
28369940
sparser
"IGF-1R phosphorylates insulin receptor substrate 1 (IRS-1), which also contains pYXXM motifs that bind the SH2 domains of p85 [ xref ]."
18641990
sparser
"The phosphorylation of the IGF-I receptor β subunit is coincidental with the tyrosine phosphorylation of its adapter IRS-1, suggesting that the IGF-I receptor phosphorylates IRS-1 in response to AngII[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10967198
sparser
"Upon binding the IGF ligand, IGF1R is activated through autophosphorylation and subsequently phosphorylates insulin receptor substrate 1 (IRS1)."
27011182
sparser
"InsR or IGF1R binds to IRS-1 via the phosphotyrosine-binding domain and phosphorylates multiple sites on tyrosine in IRS-1, leading to the association with several signaling molecules such as PI3K, GRB2 and SHP2 [ xref , xref ]."
30404198
sparser
"Upon engagement with IGFs, IGF1R phosphorylates IRS1, which then activates the PI3K/AKT/mTOR pathway to promote cartilage matrix synthesis [ xref , xref ]."
33639898
sparser
"IGF-I-stimulated autophosphorylation of the IGF-IR and tyrosine phosphorylation of IRS-1 and SHC, known substrates in the IGF-IR signal transduction pathway, were studied."
9202243
rlimsp
"IR and IGF1R are known to phosphorylate multiple IR substrates, including IRS-1, IRS-2, Shc, Gab-1 and Grb10 (ref."
28345670
reach
"IGF-I rapidly stimulated beta-chain IGF-I receptor autophosphorylation, which peaked at a physiological and mitogenic concentration (1.4 nM) and also stimulated tyrosine phosphorylation of insulin receptor substrate-1 (IRS-1)."
8756554
reach
"The phosphorylation of the IGF-I receptor beta subunit is coincidental with the tyrosine phosphorylation of its adapter IRS-1, suggesting that the IGF-I receptor phosphorylates IRS-1 in response to An[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10967198
sparser
"Indeed, the effect of IGF1 is time-limited by the phosphorylation of IRS1 by IGF1R and its subsequent ubiquitination and proteasome-mediated degradation."
33466753
reach
"While stimulation of IGF-1R by IGFs triggers autophosphorylation and subsequent phosphorylation of either insulin receptor substrate-1 (IRS-1) or insulin receptor substrate-2 (IRS-2), it is clear that these adapter proteins are activated by both IR 15 and IGF-1R."
29152592
sparser
"IGF-IR ligand binding causes phosphorylation of insulin receptor substrate-1 and -2 (IRS1, IRS2), which promote growth by transmitting signals to MAPK/ERK, PI3K/AKT and JAK/STAT in cell type specific manners [ xref , xref ]."
24565562
sparser
"As for IGF1 induced phosphorylation of IRS1, the E3 ligase that modulates IRS1 levels after IGF1R phosphorylation of IRS1 is the Fbxo40–SCF complex (Shi et al ., xref ) ( xref )."
24237131
sparser
"Since activated IGF-1R phosphorylates IRS-1, we first examined whether TRAF4 affects IGF-1-induced IGF-1R activation in control or TRAF4-overexpressing MCF-7 cells."
33991522
sparser
"Therefore, our studies define a unique signaling mechanism by which the IGF-I receptor phosphorylates IRS-1, allowing it to function as a molecular scaffold for assembly of a complex that is necessary to enable IGF-I to stimulate vimentin binding to RPTPβ ( xref )."
26773517
sparser
"Downregulation of β 1 blocks IGF-stimulated cell proliferation and transformation of prostate cancer cells ( xref ), but the effect of β 1 downregulation on activation of IGF-IR and tyrosine phosphorylation of insulin receptor substrate 1 (IRS-1) has never been described."
20333644
sparser
"After the ligand binds to the receptor, IGF-1R will be activated via autophosphorylation and will phosphorylate the insulin receptor substrate 1 (IRS-1)."
32986356
reach
"Upon binding the IGF ligand, IGF1R is activated through autophosphorylation and subsequently phosphorylates insulin receptor substrate 1 (IRS1)."
27011182
reach
"Otherwise, IGF-1R is activated through phosphorylation, and subsequently phosphorylates insulin receptor substrate 1 (IRS-1)."
29212962
sparser
"Upon ligation, IGF1R recruits and phosphorylates IRS1."
30594912
sparser
"Following IRS1 activation, IGF1R phosphorylates IRS1 leading to its ubiquitination by FBXO40 and its degradation by the 26S proteasome, in cultured myotube and in mice [22,175]."
33466753
reach
"IGF1R phosphorylates IRS1 (Insulin receptor substrate-1) and recruits its downstream effectors."
22343619
reach
"Indeed, IGF-IR internalization was required for Shc activation but not for IRS-1 phosphorylation, which was mediated by both cell surface and endosomal IGF-IR."
25566192
reach
"Upon engagement with IGFs, IGF1R phosphorylates IRS1, which then activates the PI3K/AKT/mTOR pathway to promote cartilage matrix synthesis [XREF_BIBR, XREF_BIBR]."
33639898
sparser
"Activation of PI3K thus requires both PKA-mediated relief of IRS1 inhibition and IGF-1R-dependent tyrosine phosphorylation of IRS1."
26702053
reach
"To analyze the mechanism by which stimulation of IGF-IR led to PKCzeta mediated vimentin phosphorylation, we determined if vimentin and PKCzeta were co-recruited to the scaffolding protein IRS-1, which is directly phosphorylated by IGF-IR."
26773517
sparser
"This would also suggest that, although IGF-1R-dependent IRS-1 phosphorylation is reduced in OA Obs, Syp phosphorylation and activity could compensate for this reduction."
17129375
sparser
"IGF-1R is a tyrosine kinase receptor that is activated by IGFs, the activated IGF-1R not only phosphorylates IRS-1 and SHC to activate the MAPK cascade, which stimulates cell growth and proliferation[ xref ], but also protects from apoptosis as a result of activation of PI3K-Akt through phosphorylation and subsequent inactivation of BAD[ xref ]."
24810113
reach
"1 Upon binding the IGF ligand, IGF-1R is activated through autophosporylation, and subsequently phosphorylates insulin receptor substrate 1 (IRS-1)."
25984556
reach
"Therefore, our studies define a unique signaling mechanism by which the IGF-I receptor phosphorylates IRS-1, allowing it to function as a molecular scaffold for assembly of a complex that is necessary to enable IGF-I to stimulate vimentin binding to RPTPbeta (XREF_FIG)."
26773517
reach
"Both IGF-I and IGF-II bind the tyrosine kinase receptor IGF1R, which in turn phosphorylates the insulin receptor substrates IRS-1 and IRS-2."
19261630
reach
"The homologous insulin- like growth factor 1 receptor also phosphorylates IRS-1 in a similar manner [71."
8193539
reach
"Another study from the same group [XREF_BIBR] established that phosphorylation of AKT on Thr308 and Ser473 increases following treatment of ALL cells with AICAR and demonstrated that AKT phosphorylation on Thr 308 is mediated by AMPK induced IGF-1R activation and phosphorylation of IRS-1."
22249159
rlimsp
"Moreover, the decrease in IGF-IR/pIGF-IR expression levels was associated with decreased phosphorylation of important IGF-IR targets including IRS-1, AKT, and NPM-ALK."
25884514
sparser
"Purified insulin receptor and IGF-I receptor phosphorylated recombinant baculovirus-produced IRS-1 on similar sites in vitro, and phosphorylated baculovirus-produced IRS-1 bound PtdIns 3'-kinase activity from lysates of quiescent cells."
8384986
rlimsp
"4F2 can inhibit IGF-IR autophosphorylation, IRS-1 phosphorylation and the activation of the major downstream signaling molecules AKT and mitogen-activated protein kinase."
22895605
reach
"IGF-1R phosphorylates insulin receptor substrate 1 (IRS-1), which also contains pYXXM motifs that bind the SH2 domains of p85 [XREF_BIBR]."
18641990
reach
"Insulin receptor substrate 1 (IRS-1), which is known to be phosphorylated by autoactivated IGF-1R upon ligand binding, was shown to be involved in IGF-1R-mediated 4-OH-TAM resistance."
21595894
sparser
"The activated IGF-1R recruits and phosphorylates the intracellular substrate IRS-1, and the phosphorylated IRS-1 is in turn recognized by SH2 domain–containing proteins, such as the p85 regulatory subunit of PI3K, and triggers activation of downstream signaling pathways."
33991522
reach
"TNF-alpha also reduces phosphorylation of IRS-1 and IRS-2 by IGF1R, thus inhibiting signaling of IGF-1 in muscle cell development [XREF_BIBR]."
22207907
signor
"IGF-I binding to its receptor activates the kinase activity of the receptor, which then recruits the insulin response substrate-1, causing activation of phosphatidyl-inositol-3 kinase (PI3K) to phosphorylate Akt."
15829723
reach
"The signaling cascade begins by the binding of ligand IGF (token number of 5) with the receptor (IGF-1R) which leads to the phosphorylation of IRS-1."
29787591
reach
"As for IGF1 induced phosphorylation of IRS1, the E3 ligase that modulates IRS1 levels after IGF1R phosphorylation of IRS1 is the Fbxo40 and SCF complex (XREF_FIG)."
24237131
sparser
"Wheat germ agglutinin-purified mutant receptors were as active in phosphorylating poly-(Glu,Tyr) 4:1 as wild-type IGF-I receptors, suggesting that, in intact cells, additional factors are necessary in order for the IGF-I receptor to phosphorylate IRS-1."
7852347
reach
"IGF-1 signaling begins when IGF-1 binds with its cell surface receptor, IGF-1R, forming a homodimer signaling complex, phosphorylating IGF-1R, which then phosphorylates intracellular insulin receptor substrate 1 (IRS-1) for its downstream targets."
25714651
reach
"61 Insulin receptor substrate-1 (IRS-1) levels, which is phosphorylated by IGF-IR activation, was found to predict worse disease-free survival in small (< 2 cm) OR negative tumours."
14687598
sparser
"IGF1R phosphorylates IRS1 (Insulin receptor substrate-1) and recruits its downstream effectors ( xref )."
22343619
sparser
"TNF-α also reduces phosphorylation of IRS-1 and IRS-2 by IGF1R, thus inhibiting signaling of IGF-1 in muscle cell development [ xref ]."
22207907
reach
"IGF1/IGF1R signal phosphorylates IRS1, activating PI3K and thereby also activating AKT."
32033461
reach
"Rosiglitazone enhanced the phosphorylation of insulin receptor substrate 1 (IRS1, phosphorylated at Ser 636/639), which is considered to be the main activator of the Akt and mTOR pathway by IGF-1R."
28959186
reach
"We conclude that the human IL-4R has distinct domains that have predominant roles in growth stimulation and in gene induction; possession of the I4R motif alone, although allowing 4PS/IRS -1 phosphory[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
8624803