IndraLab
Statements
Retinoic acid inhibits MAVS. 1 / 1
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"Moreover, nsp11 antagonizes type I IFN, specifically IFNβ production, activated by the retinoic acid inducible gene 1 like receptor, showing substrate specificity toward Mitochondrial Antiviral Signaling proteins (MAVS) and RIG-I (transcripts and proteins), and demonstrating that this activity was associated to the endoribonuclease activity of this protein in which transfection mutant viruses were unable to degrade MAVS mRNA and impair IFNβ production (53)."