IndraLab

Statements

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"USP7 knockout restored MM sensitivity to BTZ and induced apoptosis by stabilizing IκBα and blocking the NF-κB signaling pathway."
33967786
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"Interestingly USP7 inhibition induces apoptosis in a p53 independent manner in CLL."
28473667
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"Furthermore, XREF_FIG showed that poly ADP-ribose polymerase (PARP) cleavage and cellular apoptosis were induced by USP7 inhibition."
33869052
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"USP7 inhibition induces apoptosis in T-ALL cells ."
30370059
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"Pharmacologic inhibition of USP7 induces apoptosis in T-ALL cells."
30370059
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"We showed that inhibition of USP7 in canine lymphoma and leukemia cells may cause apoptosis."
33650720
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"To determine whether p53 mediates USP7 inhibition‐induced SnC apoptosis by upregulating pro‐apoptotic genes, we compared BBC3, PMAIP1, and FAS mRNA levels in non‐SnCs and IR‐induced SnCs with or without P5091 treatment."
32064756
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"In OSCC cells , USP7 was shown to promote cell proliferation , inhibit apoptosis , enhance cell migration and invasion , and activate the Akt / ERK pathway ."
34812471
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"20, 21 Finally, inhibition of USP7 was shown to trigger apoptosis in cancer cells by causing oxidative and endoplasmic reticulum (ER) stress."
33650720
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"Pharmacological USP7 inhibition by P5091 retarded cell proliferation and induced cell apoptosis."
31730000
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"Targeting USP7 induces growth inhibition and apoptosis in CLL cell lines."
28418900
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"P5091, a selective inhibitor of Usp7 induced apoptosis in MM cells and shown more effective when combined with HDAC inhibitor SAHA, lenalidomide or dexamethasone [XREF_BIBR]."
27261328
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"Consistently, USP7 silencing promoted MEC-1 apoptosis."
28418900
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"USP7 inhibition induces cell apoptosis and cell cycle G2/M arrest, and overcomes taxane resistance by inducing the protein degradation of PLK1, resulting in chromosome misalignment in mitosis."
31730000
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"Recently, Chauhan et al. showed that pharmacological inhibition of the de-ubiquitinase USP7 strongly induces apoptosis in multiple myeloma cells resistant to conventional and bortezomib based therapies [XREF_BIBR]."
28418900
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"Our results indicate that inhibition of USP7 leads to a disruption of cell cycle progression, and triggers DNA damage and apoptosis."
33650720
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"Our results indicated that USP7 knockdown also induces apoptosis ( Figure 2 ) ."
33869052
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"In in vitro experiments, inhibition of USP7 in GBM induced significant apoptosis."
34556124
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"Collectively, these data indicate that HPV E6/E7 induces expression of USP7, which promotes TXNIP methylation through the epigenetic regulator UHRF1, leading to enhanced cell proliferation and decreased apoptosis in cervical cancer (XREF_FIG)."
33795533
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"Furthermore , USP7 inhibition induced apoptosis in both cell groups ."
36624687
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"Meanwhile, Chauhan and colleagues indicated that the inhibitor of the deubiquitylating enzyme USP7 could induce apoptosis in myeloma cells that are resistant to conventional therapies, including bortezomib, by inhibiting HDM2 and p21."
29441489
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"The knockdown of USP7 in NSCLC cells impaired cell invasion and motility, and tumor formation, and induced cell apoptosis."
25519684
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"Here we show that ubiquitin-specific peptidase 7 (USP7) is a novel target for senolysis because inhibition of USP7 with an inhibitor or genetic depletion of USP7 by RNA interference induces apoptosis selectively in SnCs."
32064756
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"Recent studies have shown that the overexpression of USP7 in prostate cancer correlates with tumor aggressiveness and that the inhibition of USP7 can induce the apoptosis of multiple myeloma (MM) cells resistant to conventional and bortezomib therapies [XREF_BIBR, XREF_BIBR]."
25519684
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"In line with this finding, genetic or chemical inhibition of USP7 leads to BCR-ABL protein degradation, suppresses BCR/ABL signaling, and induces CML cell apoptosis."
33963175
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"Small-molecule inhibitors of USP7 induce apoptosis through oxidative and endoplasmic reticulum stress in cancer cells."
26768359
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"p53 is a key protein in mitochondrial apoptotic pathways [XREF_BIBR, XREF_BIBR], and our research found that the knockdown of USP7 expression in H460 cells can promote apoptosis, again suggesting that USP7 participates in the apoptotic pathway."
25519684
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"To elucidate the molecular basis of apoptosis inhibition mediated by USP7, we further analyzed the effects of USP7 on the Bcl-2 protein family (mitochondrial proteins critical for performing cell apoptosis)."
25519684
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"Our results indicate that inhibition of USP7 leads to a disruption of cell cycle progression , and triggers DNA damage and apoptosis ."
33650720
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"USP7 inhibition led to apoptosis of ERalpha positive breast cancer cells."
32224970
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"In fact, several studies have reported that functional inhibition of USP7 induces cancer cell apoptosis through activation of p53."
26768359
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"Moreover, the deubiquitinase USP7 has been shown to deubiquitinate several key cancer proteins, and P5091, a highly specific inhibitor of USP7, induced apoptosis in multiple myeloma cells."
29617661
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"In this regard , we discovered that knockdown of USP7 blocked T-ALL cell proliferation in vitro and in vivo , and inhibition of USP7 resulted in T-ALL cell growth suppression and apoptosis ."
30370059
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"It was found that inhibition or downregulation of USP7 could not cause cell apoptosis and necrosis of NSCLC cells by the quantified reduction in cell number."
27590858
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"Our results show that inhibition of USP7 by a small molecule or genetic depletion can selectively induce apoptosis in several types of SnCs at least in part via restoring p53 activity, which in turn induces the pro‐apoptotic proteins PUMA, NOXA, and FAS and inhibits the interaction of BCL‐XL and BAK because SnCs are more sensitive to the perturbation of mitochondrial apoptotic pathways than non‐SnCs (Chang et al., 2016; Yosef et al., 2016; Zhu et al., 2017)."
32064756
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"USP7 stimulates myeloma cell survival, and inhibition of USP7 levels using P5091 Inhibitor caused apoptosis in myeloma cell lines.79 Summary."
35005106
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"Compound 1, a selective inhibitor of USP7 and USP47 with moderate potency, demonstrates inhibition of USP7 in cells and induces elevated p53 and apoptosis in cancer cell lines."
24900381
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"These results confirm that USP7 is a novel senolytic target and inhibition of USP7 activity can selectively kill SnCs, probably in part by destabilizing MDM2 and upregulating p53.2.2 Inhibition of USP7 activity induces SnC apoptosis in part via a p53-dependent manner."
32064756
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"Our results indicated that USP7 knockdown also induces apoptosis (XREF_FIG)."
33869052
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"A USP7 inhibitor effectively induced apoptosis and suppressed metastasis in chemoresistant TNBC ."
36291159
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"Our data indicated that USP7 expression is increased during myocardial ischemia/reperfusion injury in mice, while its inhibiting suppressed the generation of oxygen free radicals and myocardial cell apoptosis, reduced myocardial tissue damage, and improved heart function."
35710902
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"A recent study demonstrated that inhibition of ubiquitin specific protease-7 (USP7), which normally stabilizes MDM2, triggers apoptosis in bortezomib resistant MM cells, confirming the idea of p53 downregulation as a DR mechanism in MM [XREF_BIBR]."
24327604
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"These findings suggest that USP7 inhibition selectively induces SnC apoptosis at least in part by increasing p53 translocation to mitochondria and its interaction with BCL‐XL, since SnCs are more dependent on BCL‐2 family proteins for survival compared to non‐SnCs (Chang et al., 2016; Yosef et al., 2016; Zhu et al., 2016)."
32064756
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"A class of dual small molecule inhibitors of USP7 and USP47 has been identified to promote p53 activity and apoptosis in MM and B-cell leukemia cells in vitro and xenograft models."
33643919
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"Notably, selective dual inhibitors of USP7 and USP47 have been synthesized and induced accumulation of p53 and apoptosis in human cancer cell lines [XREF_BIBR]."
25481052
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"Taken together, our results suggest that loss of USP7 function inhibits the melanoma cell cycle and promotes cell apoptosis by mediating AMPK and PI3K/Akt/FOXO signaling pathway activity."
33869052
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"Silencing USP7 in U-251 MG cells limited the growth of the glioma cells, promoted glioma cell apoptosis, and facilitated the proliferation of CD8+ T cells, thus inhibiting immune escape."
35852892
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"Targeting of USP7 by the inhibitor P5091 induces cellular apoptosis of cancer cells in MM and counteracts bortezomib resistance [XREF_BIBR]."
33327527
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"In OSCC cells, USP7 was shown to promote cell proliferation, inhibit apoptosis, enhance cell migration and invasion, and activate the Akt/ERK pathway."
34812471
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"In line with this finding, genetic or chemical inhibition of USP7 leads to BCR-ABL protein degradation, suppresses BCR and ABL signaling, and induces CML cell apoptosis."
33963175
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"More recently, it has been shown that a small molecule inhibitor of HAUSP, HBX41108, stabilizes p53 and induces p53 dependent apoptosis in cancer cell lines that retain wild-type p53 [XREF_BIBR]."
21624367
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"The above evidence revealed that FOXO6 upregulated the expression of USP7 in EC to inhibit the apoptosis of tumor cells and promote their proliferation."
33768140
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"Furthermore, USP7 inhibition induced apoptosis in both cell groups."
36624687
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"Therefore, it is possible that USP7 inhibition may induce SnC apoptosis not only via a p53‐dependent manner but also through a p53‐independent mechanism."
32064756
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"Here, we show that inhibitors of HAUSP and Nutlin-3 can synergistically activate p53 function and induce p53 dependent apoptosis in human cancer cells."
29616860
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"In conclusion, through inhibiting the BiP-eIF2 α -ATF4-CHOP signaling of ERS and NF- κ B/p65 signaling, USP7 promotes chondrocyte proliferation and suppresses the apoptosis and inflammatory response under TNF- α -induced inflammation."
35432716
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"Thus, USP7 is a new senolytic target and USP7 inhibitors are novel senolytic agents at least for some SnCs which downregulate their expression of p53 after they become senescent.However, USP7 has multiple targets (Pozhidaeva & Bezsonova, 2019) and p53 knockout only attenuated but did not abrogate USP7 inhibition‐induced SnC apoptosis."
32064756
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"It has been shown previously that USP7 inhibition can induce apoptosis in various cancer cells via restoration of PTEN nuclear pool (Carrà et al., 2017), inhibition of Wnt signaling (An et al., 2017), and induction of oxidative and endoplasmic reticulum stress (Lee et al., 2016)."
32064756
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"Since inhibition of USP7 induces apoptosis in neuroblastoma [28], breast cancer [29] and ovarian cancer cells [30], we hypothesized that inhibition of USP7 could also induce apoptosis in GBM."
34556124
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"The inhibition of USP7 with HBX 41,108, a DUB to Hdm2 has shown to induce p53 dependent apoptosis with an IC in sub-micro-molar concentrations."
24756373
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"Similarly , it was found that USP7 knockdown significantly increased apoptosis ( 19.51 % + / - 0.699 in ABT-737-treated control siRNA-transfected cells vs 31.34 % + / - 0.1817 in ABT-737-treated USP7-transfected cells ) ( Figure S4C-D ) ."
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"This mechanism may contribute to the selective induction of apoptosis in SnCs by USP7 inhibition because studies from our groups and others show that SnCs are more dependent on BCL‐XL for survival (Chang et al., 2016; Yosef et al., 2016; Zhu et al., 2016)."
32064756
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"This suggests that ARF4 overexpression effectively prevented early-, late-stage apoptosis and total apoptosis induced by USP7 inhibition using shRNA or P5091."
34556124
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"Suppression of USP7 induces BCR-ABL degradation and chronic myelogenous leukemia cell apoptosis."
33963175
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"In wt p53 expressing cell lines, inhibition of USP7 stabilizes p53 and promotes apoptosis."
26734569
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"However, senescent p53 knockout cells were resistant to apoptosis and cell death caused by USP7 inhibition with P5091 (Figure 3a, b)."
32064756
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"Therefore, we confirm that USP7 also as an oncogene inhibits p53 dependent apoptosis in melanoma, as in colon cancer."
33869052
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"It showed that sgUSP7 induced the cleavage of PARP (Fig. 5D), suggesting knockdown USP7 leads to CML cell apoptosis."
33963175
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"Inhibition or knock-down of USP7 has been shown to induce apoptosis through both p53 dependent and independent pathways [XREF_BIBR, XREF_BIBR]."
29236775
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"In addition, USP7 inhibition or silencing led to growth inhibition and apoptosis of ERalpha positive breast cancer cells both in vitro and in vivo."
31518603