IndraLab

Statements

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"USP7 inhibition can lead to cell growth arrest and apoptosis through inhibition of tumor promoters and stabilization of tumor suppressors, making it a promising druggable target for cancer therapy."
37789645
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"The inhibition of USP7 with HBX 41,108, a DUB to Hdm2 has shown to induce p53 dependent apoptosis with an IC in sub-micro-molar concentrations."
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"USP7 attenuates endoplasmic reticulum stress-induced apoptotic cell death through deubiquitination and stabilization of FBXO7."
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"Our results indicated that USP7 knockdown also induces apoptosis ( Figure 2 ) ."
33869052
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"Here, we show that inhibitors of HAUSP and Nutlin-3 can synergistically activate p53 function and induce p53 dependent apoptosis in human cancer cells."
29616860
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"Correction: USP7 attenuates endoplasmic reticulum stress-induced apoptotic cell death through deubiquitination and stabilization of FBXO7."
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"It has been demonstrated that suppression of USP7 by genetic depletion selectively induced apoptosis of senescent cells via restoration of p53 activity [31]."
38057857
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"Knockdown of either USP7 or PLK1 induces cell apoptosis and cell cycle G2/M arrest, resulting in reduced taxane resistance [111]."
36694209
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"In addition, the expression of USP7 is increased during myocardial ischemia/reperfusion injury in mice, while it inhibits the production of oxygen free radicals and myocardial cell apoptosis, reduces myocardial tissue damage, and improves cardiac function [47]."
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"A class of dual small molecule inhibitors of USP7 and USP47 has been identified to promote p53 activity and apoptosis in MM and B-cell leukemia cells in vitro and xenograft models."
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"Recent studies have shown that the overexpression of USP7 in prostate cancer correlates with tumor aggressiveness and that the inhibition of USP7 can induce the apoptosis of multiple myeloma (MM) cells resistant to conventional and bortezomib therapies [XREF_BIBR, XREF_BIBR]."
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"The knockdown of USP7 in NSCLC cells impaired cell invasion and motility, and tumor formation, and induced cell apoptosis."
25519684
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"Our laboratory and others have demonstrated that inhibition of ubiquitin specific peptidase 7 could enhance the degradation of NOTCH1 and induce proliferation inhibition and apoptosis of T-ALL cells i[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"To elucidate the molecular basis of apoptosis inhibition mediated by USP7, we further analyzed the effects of USP7 on the Bcl-2 protein family (mitochondrial proteins critical for performing cell apoptosis)."
25519684
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"In conclusion, through inhibiting the BiP-eIF2 α -ATF4-CHOP signaling of ERS and NF- κ B/p65 signaling, USP7 promotes chondrocyte proliferation and suppresses the apoptosis and inflammatory response under TNF- α -induced inflammation."
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"Furthermore, USP7 inhibition induced apoptosis in both cell groups."
36624687
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"A recent study demonstrated that inhibition of ubiquitin specific protease-7 (USP7), which normally stabilizes MDM2, triggers apoptosis in bortezomib resistant MM cells, confirming the idea of p53 downregulation as a DR mechanism in MM [XREF_BIBR]."
24327604
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"Single treatment with either low dose agents was unable to induce apoptosis; notably, the combination of HAUSP and Mdm2 inhibition which strikingly activated p53 levels, also induced apoptosis."
29616860
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"USP7 inhibition induces substantial apoptosis accompanied by G1 arrest in CHP-212 cells ."
40087304
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"p53 is a key protein in mitochondrial apoptotic pathways [XREF_BIBR, XREF_BIBR], and our research found that the knockdown of USP7 expression in H460 cells can promote apoptosis, again suggesting that USP7 participates in the apoptotic pathway."
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"Collectively, this study suggests that USP7 inhibition may accelerate the osseointegration process in senile osteoporotic conditions by promoting macrophage efferocytosis and aged BMSCs apoptosis."
39651622
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"Inhibition of USP7 can activate the MDM2-P53 signaling pathway, thereby promoting cancer cell apoptosis."
38361286
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"In OSCC cells, USP7 was shown to promote cell proliferation, inhibit apoptosis, enhance cell migration and invasion, and activate the Akt/ERK pathway."
34812471
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"The suppression of USP7 in glioma cells hampers their growth and induces apoptosis."
38474186
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"Interestingly USP7 inhibition induces apoptosis in a p53 independent manner in CLL."
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"Ubiquitin-specific peptidase 7, a widely studied deubiquitinase, promoted chondrocyte proliferation and suppressed tumour necrosis factor alpha (TNF-α)-induced apoptosis and inflammation via inhibiting eIF2α-ATF4-CHOP signaling and nuclear factor-kappa B (NF-κB)/p65 signaling, thereby preventing the occurrence of OA [56, 57]."
37941072
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"Our finding suggests that EZH2, a tumorigenesis-related gene, can change transcriptional profile by abnormally establishing facultative heterochromatin at euchromatic regions.Both STAT3 and USP7 promote cell proliferation and prevent apoptosis [ [23,[30], [31], [32]]], and are advantageous to cancer cells’ survival."
37829803
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"USP7 also prevents apoptosis by stabilizing MDM2, which further destabilizes apoptotic factor p53 [23,31]."
37829803
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"However, another study reported that USP7 promotes chondrocyte proliferation and inhibits apoptosis and tumor necrosis factor-α-induced inflammatory response by inhibiting the BiP-eIF2α-ATF4-CHOP signaling pathway and NF-κB/p65 signaling pathway of endoplasmic reticulum stress [34]."
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"Inhibition of USP7 has been shown to increase p53 stability, thus promoting cancer cell apoptosis [ 12–14 ]."
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"Conversely, re-expression of FGFR1 weakened cell apoptosis induced by reduced USP7 expression (Figure 4E)."
39037153
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"Furthermore, XREF_FIG showed that poly ADP-ribose polymerase (PARP) cleavage and cellular apoptosis were induced by USP7 inhibition."
33869052
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"P5091, a selective inhibitor of Usp7 induced apoptosis in MM cells and shown more effective when combined with HDAC inhibitor SAHA, lenalidomide or dexamethasone [XREF_BIBR]."
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"USP7 inhibition induced more apoptosis and suppressed angiogenesis in USP22-Ko cancer cells."
37946202
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"Taken together, our results suggest that loss of USP7 function inhibits the melanoma cell cycle and promotes cell apoptosis by mediating AMPK and PI3K/Akt/FOXO signaling pathway activity."
33869052
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"USP7 inhibition led to apoptosis of ERalpha positive breast cancer cells."
32224970
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"Inhibition or knock-down of USP7 has been shown to induce apoptosis through both p53 dependent and independent pathways [XREF_BIBR, XREF_BIBR]."
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"The overexpression of USP7 significantly inhibited the apoptosis of chondrocytes and promoted the proliferation of chondrocyte ( Fig. 4 D–G)."
38266448
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"The suppression of USP7 significantly promoted the apoptosis of chondrocytes and inhibited the proliferation of chondrocyte ( Fig. 4 D–G)."
38266448
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"Our results indicated that USP7 knockdown also induces apoptosis (XREF_FIG)."
33869052
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"Therefore, we confirm that USP7 also as an oncogene inhibits p53 dependent apoptosis in melanoma, as in colon cancer."
33869052
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"USP7 stimulates myeloma cell survival, and inhibition of USP7 levels using P5091 Inhibitor caused apoptosis in myeloma cell lines.79 Summary."
35005106
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"Targeting of USP7 by the inhibitor P5091 induces cellular apoptosis of cancer cells in MM and counteracts bortezomib resistance [XREF_BIBR]."
33327527
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"This indicate that USP7 knockdown causes development arrest by inducing cell apoptosis in mouse early embryo.Epigenetic reprogramming is an important event in early embryonic development."
37080417
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"Suppression of USP7 induces BCR-ABL degradation and chronic myelogenous leukemia cell apoptosis."
33963175
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"On contrary, Dong X et al. reported that USP7 expression was inhibited in mice with post-trauma OA, and silencing USP7 negatively regulated chondrocyte proliferation and promoted cell apoptosis."
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"The inhibition of ubiquitin-specific peptidase 7 selectively induces the apoptosis of senescent cells."
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"In line with this finding, genetic or chemical inhibition of USP7 leads to BCR-ABL protein degradation, suppresses BCR/ABL signaling, and induces CML cell apoptosis."
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"Similarly , it was found that USP7 knockdown significantly increased apoptosis ( 19.51 % + / - 0.699 in ABT-737-treated control siRNA-transfected cells vs 31.34 % + / - 0.1817 in ABT-737-treated USP7-transfected cells ) ( Figure S4C-D ) ."
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"It showed that sgUSP7 induced the cleavage of PARP (Fig. 5D), suggesting knockdown USP7 leads to CML cell apoptosis."
33963175
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"Targeting USP7 induces growth inhibition and apoptosis in CLL cell lines."
28418900
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"Compound 1, a selective inhibitor of USP7 and USP47 with moderate potency, demonstrates inhibition of USP7 in cells and induces elevated p53 and apoptosis in cancer cell lines."
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"USP7 inhibition induces apoptosis of tumor cells and prolonged survival in an experimental multiple myeloma and neuroblastoma mouse model [57,58] ."
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"These indicated that DNA damage and blastocyst cell apoptosis caused by USP7 knockdown might be the cause of embryo development arrest.H3K27me3 is one of important epigenetic modifications during prei[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
37080417
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"Recently, Chauhan et al. showed that pharmacological inhibition of the de-ubiquitinase USP7 strongly induces apoptosis in multiple myeloma cells resistant to conventional and bortezomib based therapies [XREF_BIBR]."
28418900
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"These data suggest that functional RNF4 and USP7 are critical for TKO cells to suppress apoptosis induced by bortezomib and that RNF4 plays a dominant role in modulating cell sensitivity.2.4."
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"Moreover, the deubiquitinase USP7 has been shown to deubiquitinate several key cancer proteins, and P5091, a highly specific inhibitor of USP7, induced apoptosis in multiple myeloma cells."
29617661
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"The results showed that the TUNEL-positive cells were increased by P5091 treatment, indicating that USP7 inhibition induced tumor apoptosis ( Fig. 5 G)."
31518603
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"Immunochemical staining and TUNEL analysis showed that USP7 silence triggered tumor apoptosis ( Fig. 5 J and K, Fig. S2K )."
31518603
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"Consistently, USP7 silencing promoted MEC-1 apoptosis."
28418900
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"USP7 Inhibition Induces Cell Apoptosis in TP53 Wild-Type Neuroblastoma Cells."
37762082
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"Collectively, these data indicate that HPV E6/E7 induces expression of USP7, which promotes TXNIP methylation through the epigenetic regulator UHRF1, leading to enhanced cell proliferation and decreased apoptosis in cervical cancer (XREF_FIG)."
33795533
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"In a xenograft mouse model, USP7 inhibition mediated p53‐dependent cell‐cycle arrest and apoptosis."
33157193
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"For example, USP7 overexpression has been linked to bortezomib resistance, and a small molecule inhibitor (P5091) of USP7 has been shown to overcome this resistance and produce apoptosis in myeloma cells [47]."
36768967
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"To study the molecular mechanism by which the inhibition of USP7 induces cellular apoptosis, we determined levels of several classical pro-apoptotic and anti-apoptotic proteins, including PARP and Bcl[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31518603
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"Our data indicated that USP7 expression is increased during myocardial ischemia/reperfusion injury in mice, while its inhibiting suppressed the generation of oxygen free radicals and myocardial cell apoptosis, reduced myocardial tissue damage, and improved heart function."
35710902
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"USP7 is thought to inhibit the ubiquitination process of MDM2 and MDM4, and inhibition of USP7 expression induces apoptosis and leads to cell cycle arrest in tumors (50, 51)."
36530999
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"USP7 inhibition triggers p53-dependent apoptosis in cancer cells ( Mungamuri et al., 2016 ; Zhou et al., 2018 ; Gao et al., 2021 ) as well as in senescent fibroblasts ( He et al., 2020 ), mainly in re[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
36130505
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"USP7 inhibition induced apoptosis in all TP53 wild-type NB cell lines."
37762082
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"USP7 inhibition induces apoptosis in T-ALL cells ."
30370059
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"Inhibition of USP7 Induces Apoptosis of Chemoresistant TNBC."
36291159
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"It was found that inhibition or downregulation of USP7 could not cause cell apoptosis and necrosis of NSCLC cells by the quantified reduction in cell number."
27590858
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"Furthermore , USP7 inhibition induced apoptosis in both cell groups ."
36624687
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"In this regard , we discovered that knockdown of USP7 blocked T-ALL cell proliferation in vitro and in vivo , and inhibition of USP7 resulted in T-ALL cell growth suppression and apoptosis ."
30370059
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"Moreover, inhibition of USP7 induces apoptosis and cell cycle arrest in the G2/M phase."
39885534
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"The knockdown of the USP7 gene can reduce the proliferation of PCa cells and induce their apoptosis (Shin et al., 2020)."
36811009
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"Indeed, recent studies have shown that the USP7-specific inhibitor, P22077, induces apoptosis in a p53-dependent manner in colon carcinoma and neuroblastoma [3,4] ."
26768359
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"A USP7 inhibitor effectively induced apoptosis and suppressed metastasis in chemoresistant TNBC ."
36291159
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"Notably, selective dual inhibitors of USP7 and USP47 have been synthesized and induced accumulation of p53 and apoptosis in human cancer cell lines [XREF_BIBR]."
25481052
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"More recently, it has been shown that a small molecule inhibitor of HAUSP, HBX41108, stabilizes p53 and induces p53 dependent apoptosis in cancer cell lines that retain wild-type p53 [XREF_BIBR]."
21624367
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"According to the former study, it showed that through inhibiting the BiP-eIF2α-ATF4-CHOP signaling of ERS and NF-κB/p65 signaling, USP7 promotes chondrocyte proliferation and suppresses the apoptosis and inflammatory response under TNF-α-induced inflammation [71]."
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"Although USP7 deletion induces p53-dependent neuronal apoptosis, most behavioral abnormalities in USP7 conditional knockout mice persist following p53 loss."
39862434
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"Our results indicate that inhibition of USP7 leads to a disruption of cell cycle progression , and triggers DNA damage and apoptosis ."
33650720
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"Here we show that ubiquitin-specific peptidase 7 (USP7) is a novel target for senolysis because inhibition of USP7 with an inhibitor or genetic depletion of USP7 by RNA interference induces apoptosis selectively in SnCs."
32064756
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"USP7 prevents p53-dependent neuronal apoptosis."
39862434
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"Pharmacologic inhibition of USP7 induces apoptosis in T-ALL cells."
30370059
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"Our results show that inhibition of USP7 by a small molecule or genetic depletion can selectively induce apoptosis in several types of SnCs at least in part via restoring p53 activity, which in turn induces the pro‐apoptotic proteins PUMA, NOXA, and FAS and inhibits the interaction of BCL‐XL and BAK because SnCs are more sensitive to the perturbation of mitochondrial apoptotic pathways than non‐SnCs (Chang et al., 2016; Yosef et al., 2016; Zhu et al., 2017)."
32064756
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"Collectively, these results suggest that pharmacological inhibition of USP7 leads to oxidative stress in an ER stress-dependent manner, but independently of p53 status.Since high levels of intracellul[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26768359
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"These findings suggest that loss of USP7 function in glutamatergic neurons in the forebrain might be relevant to HAFOUS.In developmental studies, USP7 deletion causes p53-dependent apoptosis in post-mitotic glutamatergic neurons."
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"USP7 inhibition induced apoptosis in all TP53 wild-type NB cell lines ."
37762082
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"In LUSC and large cell carcinomas, inhibition of USP7 promotes cancer cell apoptosis through the MDM2-p53 axis [31]."
35948545
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"These results confirm that USP7 is a novel senolytic target and inhibition of USP7 activity can selectively kill SnCs, probably in part by destabilizing MDM2 and upregulating p53.2.2 Inhibition of USP7 activity induces SnC apoptosis in part via a p53-dependent manner."
32064756
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"In wt p53 expressing cell lines, inhibition of USP7 stabilizes p53 and promotes apoptosis."
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"However, senescent p53 knockout cells were resistant to apoptosis and cell death caused by USP7 inhibition with P5091 (Figure 3a, b)."
32064756
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"These results suggest that oxidative stress mainly involves USP7 inhibitor-mediated anticancer effects.In conclusion, the major findings are that (1) USP7 inhibition causes ER stress through accumulat[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26768359
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"This mechanism may contribute to the selective induction of apoptosis in SnCs by USP7 inhibition because studies from our groups and others show that SnCs are more dependent on BCL‐XL for survival (Chang et al., 2016; Yosef et al., 2016; Zhu et al., 2016)."
32064756
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"Suppression of USP7 activity induces apoptosis and suppresses metastasis in estrogen receptor-positive breast cancer cells."
39985032
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"In developmental analyses of the cerebral cortex, USP7 deletion induces neuronal apoptosis, which is rescued by loss of the tumor suppressor protein p53, an established downstream mediator of USP7 signaling."
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"Herein, functional assays showed that the inhibition of USP7 decreased cell proliferation migration and invasion abilities but increased apoptosis in ERPBC."
39985032
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"USP7 inhibition can lead to cell growth arrest and apoptosis through inhibition of tumor promoters and stabilization of tumor suppressors , making it a promising druggable target for cancer therapy ."
37789645
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"To determine whether p53 mediates USP7 inhibition‐induced SnC apoptosis by upregulating pro‐apoptotic genes, we compared BBC3, PMAIP1, and FAS mRNA levels in non‐SnCs and IR‐induced SnCs with or without P5091 treatment."
32064756
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"These findings suggest that USP7 inhibition selectively induces SnC apoptosis at least in part by increasing p53 translocation to mitochondria and its interaction with BCL‐XL, since SnCs are more dependent on BCL‐2 family proteins for survival compared to non‐SnCs (Chang et al., 2016; Yosef et al., 2016; Zhu et al., 2016)."
32064756
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"Inhibition of USP7 activity repressed proliferation, induced apoptosis, suppressed migration and invasive activities, and reversed the epithelial-mesenchymal transition of ERPBC."
39985032
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"Our results indicate that inhibition of USP7 leads to a disruption of cell cycle progression, and triggers DNA damage and apoptosis."
33650720
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"Meanwhile, Chauhan and colleagues indicated that the inhibitor of the deubiquitylating enzyme USP7 could induce apoptosis in myeloma cells that are resistant to conventional therapies, including bortezomib, by inhibiting HDM2 and p21."
29441489
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"The above evidence revealed that FOXO6 upregulated the expression of USP7 in EC to inhibit the apoptosis of tumor cells and promote their proliferation."
33768140
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"Thus, USP7 is a new senolytic target and USP7 inhibitors are novel senolytic agents at least for some SnCs which downregulate their expression of p53 after they become senescent.However, USP7 has multiple targets (Pozhidaeva & Bezsonova, 2019) and p53 knockout only attenuated but did not abrogate USP7 inhibition‐induced SnC apoptosis."
32064756
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"Therefore, it is possible that USP7 inhibition may induce SnC apoptosis not only via a p53‐dependent manner but also through a p53‐independent mechanism."
32064756
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"It has been shown previously that USP7 inhibition can induce apoptosis in various cancer cells via restoration of PTEN nuclear pool (Carrà et al., 2017), inhibition of Wnt signaling (An et al., 2017), and induction of oxidative and endoplasmic reticulum stress (Lee et al., 2016)."
32064756
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"The results showed that USP7 overexpression significantly inhibited sorafenib-mediated proliferation inhibition, cell death, and apoptosis induction, which was reversed by c-Myc silencing (p<0.01) (Figure 2H–J)."
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"In in vitro experiments, inhibition of USP7 in GBM induced significant apoptosis."
34556124
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"Since inhibition of USP7 induces apoptosis in neuroblastoma [28], breast cancer [29] and ovarian cancer cells [30], we hypothesized that inhibition of USP7 could also induce apoptosis in GBM."
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"In OSCC cells , USP7 was shown to promote cell proliferation , inhibit apoptosis , enhance cell migration and invasion , and activate the Akt / ERK pathway ."
34812471
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"20, 21 Finally, inhibition of USP7 was shown to trigger apoptosis in cancer cells by causing oxidative and endoplasmic reticulum (ER) stress."
33650720
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"This suggests that ARF4 overexpression effectively prevented early-, late-stage apoptosis and total apoptosis induced by USP7 inhibition using shRNA or P5091."
34556124
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"Inhibition of USP7 by P5091 (compound 1) was shown to cause apoptosis of multiple myeloma cells and prolonged survival in animal xenograft models ( Chauhan et al., 2012 )."
29056420
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"We showed that inhibition of USP7 in canine lymphoma and leukemia cells may cause apoptosis."
33650720
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"USP7 knockout restored MM sensitivity to BTZ and induced apoptosis by stabilizing IκBα and blocking the NF-κB signaling pathway."
33967786
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"Silencing USP7 in U-251 MG cells limited the growth of the glioma cells, promoted glioma cell apoptosis, and facilitated the proliferation of CD8+ T cells, thus inhibiting immune escape."
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"P5091, a small molecule inhibitor of USP7, which can inhibit the proliferation of CRC cells and induce apoptosis in vitro."
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"Carrà and colleagues found that USP7 reduces apoptosis in CLL cells."
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