IndraLab

Statements

Phosphorylated AKT leads to the phosphorylation of NOS3. 4 / 4
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"However, Dimmeler et al. [XREF_BIBR] previously observed via eNOS immunoprecipitation and phosphoamino acid analysis a significant increase in Akt phosphorylation following exposure to a shear stress magnitude of 5 dyn/cm 2 (i.e., 0.5 Pa), and determined Akt phosphorylation significantly increased eNOS phosphorylation."
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"The inhibition of AKT phosphorylation by treatment with the PI3-K inhibitor LY294002 reduced eNOS phosphorylation and NO production, leading to the suppression of angiogenesis in vitro."
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"Phosphorylated Akt stimulates phosphorylation of eNOS and NO production in cultured endothelial cells and endothelial progenitor cells (EPC) [22,23,24]."
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"These results suggested that AKT phosphorylation contributed to eNOS expression and phosphorylation."
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