IndraLab

Statements

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"Therefore, USP18 inhibits the immune response by reversing protein ISGylation and directly inhibiting IFN signaling pathway [ 39 ]."
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"In addition, independent of its enzymatic activity, USP18 can inhibit the type 1 interferon (IFN-1) signal transduction by binding the Interferon-alpha/beta receptor (IFNAR2) [18]."
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"Mechanistic insights revealed that USP18 inhibits osteoclastogenesis by suppressing the NF-κB signaling pathway, with a potential target on TAK1 or its upstream molecules."
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"Through IFNAR1/2 receptors and the JAK/STAT signaling pathway, IFN-I has a further impact on the next important component of the development of the inflammatory response: the ISG15/USP18 axis, which regulates the activity of the immune system [36] and reduces the inflammatory response intensity by inhibiting the JAK/STAT signaling pathway, indicating that there possibly exists a negative feedback loop between USP18, IFN-I, and, therefore, TNF-α [43, 44]."
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"This study indicates that hypoxia promotes osteoclast differentiation through the downregulation of USP18, which, in turn, relieves the suppression of the activation of the NF-κB signaling pathway."
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"Previous studies indicated that USP18 inhibited inflammation by negatively regulating NF-κB signaling pathway [31,32], and GSDMD-N terminal fragments form transmembrane pores to enable the release of IL-1β [33–35]."
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"This interaction reinforces the USP18-mediated inhibition of the IFN receptor signalling pathway."
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"25 Since ISG15 and USP18 negatively regulate IFN signaling pathway, 61,62 they are expected to act as broad pro-viral ISGs."
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"In humans, USP18 negatively regulates the JAK–STAT signaling pathway, and is therefore considered to be an inhibitor of type-I anti-viral signaling ( Malakhov et al., 2002, 2003 )."
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"For instance, USP18, a negative regulator of IFN response, inhibits JAK-STAT signaling pathway (45)."
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"Interestingly, USP18 has been shown to negatively regulate the type I IFN signalling pathway, and its deficiency results in enhanced and prolonged STAT1 phosphorylation XREF_BIBR - XREF_BIBR."
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