IndraLab

Statements

reach
"The non-covalent interactions of ISG15 and USP18 prevent the ubiquitination of USP18 by S-phase kinaseassociated protein two and stabilize the downregulation of the IFN signaling pathway by USP18 (Tokarz et al., 2004; Zhang et al., 2015) ."
34901029
reach
"Interestingly, USP18 has been shown to negatively regulate the type I IFN signalling pathway, and its deficiency results in enhanced and prolonged STAT1 phosphorylation XREF_BIBR - XREF_BIBR."
21886806
reach
"USP18 can interact with IFNAR2 and STAT2, competing with JAK1 for receptor binding and thus inhibiting signal transduction."
32039148