IndraLab

Statements

reach
"This is consistent with previous reports that USP7 contributes to transcription-coupled nucleotide excision repair of UV-induced DNA lesions by stabilizing UVSSA and that depletion of USP7 increases U[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26673319
reach
"USP7 removes polyubiquitin chains from p65 and promotes transcription by increasing the stability and half-life of transcriptionally active p65 [36]."
36077078
reach
"We therefore concluded that the mechanism by which USP7 regulates IgA GLT and switching in primary mouse B cells differed slightly in that it positively influenced the stability of both RUNX3 and CREB[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
38735043
reach
"In SAMe-D cells derived from MAT1A KO mice, sustained LKB1 phosphorylation contributes to increased cytoplasmic HuR localization, where it, specifically, binds to the 3′-UTR of herpesvirus-associated ubiquitin-specific protease (HAUSP) mRNA, stabilizing it and increasing its transcription."
35681645
sparser
"The purified TEF1 was able to activate transcription from the TGF-α promoter in an in vitro transcription assay."
10076050
reach
"In addition, K63 polyubiquitinated HAUSP serves as a scaffold to anchor HIF-1alpha, CBP, the mediator complex, and the super and elongation complex to enhance the gene transcription activity initiated by HIF-1alpha binding to the hypoxia response element in the promoters of HIF-1alpha target genes, including VEGF, Glut1, and Twist1 [XREF_BIBR]."
30176860
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"For example, prior studies have shown that knockdown of USP7 prevents rapid inactivation of the anti-proliferative transcription factor, FOXO4, providing a mechanism to impair the pro survival PI3K and Akt pathway that is commonly activated in MM 60."
27118403
reach
"USP7 inhibition results in PRC1.1 disassembly and loss of chromatin binding, coinciding with reduced H2AK119ub and H3K27ac levels and diminished gene transcription of active PRC1.1-controlled loci, whereas H2AK119ub marks are also lost at PRC1 loci."
34113809
eidos
"A study reported that USP7 is critical for target gene transcription , whereby USP7 targeted NF-kappaB p65 for K48-linked deubiquitination , increased the protein stability of p65 , and ultimately led to increased transcription ."
33511009