IndraLab

Statements

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"PAD-1 is thought to inhibit EV release by activating the phospholipid flippase TAT-5 to maintain phosphatidylethanolamine (PE) asymmetry in the plasma membrane."
36188098
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"Both single mutants are superficially wild-type and display essentially normal neuronal morphology, validating the approach of screening for suppression of non-neuronal phenotypes as a means to find rare mutations that may not be isolated based on their neuronal phenotypes.PAD-1/Dopey proteins have multiple functions in membrane trafficking: in C. elegans embryos, PAD-1 inhibits the release of ectosome-type EVs from the plasma membrane and promotes phagocytosis of cell corpses and debris by regulating the activity of TAT-5 flippase ."
38766017