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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

USP6 inhibits Radiation Tolerance. 2 / 2

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"We demonstrated that depletion of USP6 causes significantly increased radiosensitivity to high-LET IR ( low-energy protons and alpha-particles ) , but not low-LET IR ( high-energy protons or x-ray irradiation ) , which is mediated by instability of PARP-1 protein levels , a subsequent deficiency in CDD repair , and G2 / M cell cycle checkpoint arrest ."

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"We recently demonstrated using a DUB siRNA screen , that depletion of USP6 causes significantly increased radiosensitivity to high-LET IR ( relatively high-LET protons and alpha-particles ) but not low-LET IR ( protons or X-rays ) , which was mediated by instability of PARP-1 required for CDD repair ( 7 ) ."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...