IndraLab

Statements

KCNMA1 binds BK. 3 / 3
| 3
sparser
"In vascular smooth muscle, association of BK β1 with slo1 increases the channel’s apparent Ca 2+ -sensitivity, which allows activation of BK channels at physiological negative voltages."
28012000
sparser
"To determine whether BK β1 TM1, TM2 or both are critical to provide the characteristic ion current phenotype of BK β1-containing BK channels, we combined surface protein biotinylation assays with patch-clamp studies under wide voltage and Ca 2+ i ranges (which included the values found in the SM myocyte under physiological conditions) on heteromeric BK complexes resulting from the association of rat cerebral artery SM slo1 (“cbv1”) with engineered BK β1."
25275635
sparser
"Since slo1 proteins often associate with various β subunits to form BK channels in vivo ( xref ; xref ; xref ; xref ; xref ; xref ; xref ; xref ; xref ) and it is known that β1 and β2 subunits affect apparent Ca 2+ sensitivity of the channel ( xref ; xref , xref ; xref ; xref ; xref ; xref ; xref , xref ; xref ; xref ; xref ), it will be interesting to examine if Mg 2+ -dependent activation is also affected by β subunits."
16344323