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USP15 deubiquitinates H2B-Ub dimers. 1 / 1
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"Notably, human Usp15 also preferentially deubiquitinates H2A and H2B-Ub dimers and is stimulated by the splicing factor SART3, although in this case SART3 has the inverse effect : it enhances the activity of Usp15 on H2A and H2B-Ub but not on nucleosomes."