IndraLab

Statements

IL1B increases the amount of TRPC3. 4 / 4
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"Interleukin-1beta specifically upregulated TRPC3 protein expression in myometrial cells without influencing TRPC3 mRNA and had no effect of TRPC4 mRNA or protein [XREF_BIBR]."
19523685
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"Specifically, IL1B modulates protein expression of TRPC3 (a putative calcium channel) and SR Ca 2+ -ATPases, initiates spontaneous [Ca 2+] i oscillations and augments calcium influx pathways and a store operated current [XREF_BIBR, XREF_BIBR]."
17570168
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"IL-1 beta did not alter TrpC1, 3, 4, 6, or 7 mRNA expression; but IL-1 beta exclusively up-regulated TrpC3 protein expression (P < or = 0.05)."
15001625
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"The induction of TRPC3 protein expression by IL1B may in part explain the increase in TRPC3 expression observed in uterine muscle at labour onset and provides a plausible mechanism by which cytokines could induce premature labour."
17570168