IndraLab

Statements

OTUD4 is methylated. 46 / 46
| 46
sparser
"DNA methylation in AKR1B1, TM6SF1, TMEFF2, RASSF1, CCND2, HIN1, RARB, and TWIST1 genes were examined."
27261491
sparser
"The high methylated HIN1 suppress itself expression in PCa, which exhibits tumor suppressor function and inhibits tumor cell growth, invasion by activation of AKT ( Krop et al., 2005 )."
29966681
sparser
"A study has shown that parthenolide reversed the methylation of the HIN1 gene and induced re-expression in MCF-7 breast cancer cells."
37077808
sparser
"This analysis showed that TGFβR2, CALCA , HIC1 , SOCS1, RARβ, COX2 , CDH1 , THBS1 , HIN1 , CDKN2B , UCHL1 , CCND2 , MT1G and DCC were frequently methylated in control samples, showing low specificity (Table  xref )."
24359512
sparser
"Among these genes, APC [ xref ], p16 [ xref ], RASSF1A [ xref ], DAPK1 [ xref ], CDH1 [ xref ], RARβ [ xref ], GSTP1 [ xref ], CyclinD2 [ xref ], HIN1 [ xref ] and TWIST [ xref ] are frequently methylated in breast cancer."
21837480
sparser
"Although the evidence linking HIN1 levels to NB phenotype is unknown, our previous study indicated that methylation of HIN1 is associated with poor outcome in NB [ xref ]."
22863973
sparser
"According to a study [ xref ], methylation of HIN1, TFPI-2, DACH1 and SOX17 can be used as markers for early detection of esophageal cancer."
36611908
sparser
"Specifically, patients with ER+ or PR+ tumors had more frequent methylation of HIN1 and RASSF1A than those with ER- or PR- tumors."
21837480
sparser
"Tamoxifen did not modulate methylation of CCND2, HIN1, CST6, or RAR-β2, but the mean difference for the sum of APC and RASSF1A methylation fractions between post-treatment and baseline samples was +7.1% for placebo subjects and −3.5% for tamoxifen subjects (P = 0.021)."
21778330
sparser
"In tissue samples, 14-3-3-sigma, DAPK, CCND2, RASSF1A, CALCA, APC, HIN1, RARbeta2, TIG1, and GSTP1 methylation levels differed significantly among BCa, FB, and NT."
17549626
sparser
"In situ case tumors had more frequent methylation of HIN1 than invasive cancers (P=0.02)."
21837480
sparser
"Hormone receptor status of the case tumor was also positively associated with a high frequency of HIN1 and RASSF1A methylation ( P =0.02 and P =0.009, respectively)."
21837480
sparser
"For this study, 514 samples obtained from 150 women were assessed cytologically and by Quantitative Multiplex Methylation-Specific PCR (QM-MSP) for methylation of cyclin D2, APC, HIN1, RASSF1A, and RAR-beta2."
| PMC
sparser
"BMI 25-29.9kg/m 2 , and perhaps BMI≥30kg/m 2 , was associated with methylated HIN1 in breast tumor tissue."
26005715
sparser
"RASSF1A , TWIST1, and HIN1 cumulative gene methylation accurately distinguished cells washed from ducts with cancerous vs. benign lesions (100% sensitivity, 72% specificity and AUC of 0.91 according to ROC analyses)."
| PMC
sparser
"While biologically plausible, our findings that BMI is associated with methylated HIN1 and BMI/RPA are associated with ER+PR+ breast tumors in the presence of unmethylated ESR1 and methylated GSTP1 , respectively, warrant further investigation."
26005715
sparser
"Although we observed elevated likelihood of methylated HIN1 in breast tumors among women with BMI ≥30kg/m 2 , the estimate was less pronounced and included the null (OR=1.44, 91% CI: 0.94-2.23)."
26005715
sparser
"CYCLIND2, GSTP1 , and HIN1 promoter methylation also appeared to modify the associations between obesity and BC-specific mortality, but the interaction was of borderline significance ( p < 0.10)."
26945992
sparser
"Methylation of cyclin D2, APC, HIN1, RASSF1A, and RAR-beta2 was measured by quantitative multiplex methylation-specific PCR in 290 benign and malignant breast epithelial cell samples obtained by palpation-directed fine-needle aspiration biopsy from 164 women."
18483325
sparser
"514 NDL samples obtained from 150 women selected to represent a wide range of breast cancer risk were evaluated cytologically and by quantitative multiplex methylation-specific PCR for methylation of cyclin D2, APC, HIN1, RASSF1A, and RAR-beta2."
17855699
sparser
"RARB, HIN1, BCL2, GSTP1, CCND2, EGFR5, APC, RASSF1A, MDR1, NKX2-5, CDH13, DPYS, PTGS2, EDNRB, MAL, PDLIM4, HLAa, ESR1 and TIG1 were highly methylated in PCa compared to BPH (p < 0.001), while SERPINB5, CDH1, TWIST1, DAPK1, THRB, MCAM, SLIT2, CDKN2a and SFN were not."
21694441
sparser
"AP2 methylation is associated with gender ( P < 0.05), DACT2 methylation is associated with age, gender and tumor size (all P < 0.05), HIN1 methylation is associated to tumor size ( P < 0.05) and extra-thyroidal extension ( P < 0.01)."
34539742
sparser
"For heterogeneity analysis, AP2 methylation heterogeneity is associated with tumor size ( P < 0.01), CDH1 methylation heterogeneity is associated with lymph node metastasis ( P < 0.05), DACT2 methylation heterogeneity is associated with tumor size ( P < 0.01), HIN1 methylation heterogeneity is associated with tumor size and extra-thyroidal extension (all P < 0.01)."
34539742
sparser
"Indeed, mortality is lower only among physically active women with promoter methylation of APC , CCND2 , HIN1 , and TWIST1 in tumors, but not in those with unmethylated tumor markers."
36612320
sparser
"Synthetic log use was associated with elevated odds of HIN1 methylation (OR=2.14, 95%CI= 1.34–3.42) and CDH1 methylation (OR=2.26, 95%CI= 1.06–4.79) ( xref )."
26671626
sparser
"Beyond using peripheral blood, pathologic nipple discharge was applied in a study of RASSF1A, TWIST1 , and HIN1 gene methylation, which showed to accurately distinguish between ducts with cancerous[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20471512
sparser
"Ever active smoking, while not included in our a priori exposures of interest, was additionally found to be associated with decreased odds of methylation of ESR1 (OR=0.69, 95%CI 0.52–0.92) and HIN1 (OR=0.66, 95%CI 0.48–0.91) ( xref )."
26671626
sparser
"HIN1 methylation is associated with tumor size ( P < 0.05) and extra-thyroidal extension ( P < 0.01), while no association is found between HIN1 methylation and age, tumor location, TNM stage, and lymph node metastasis (all P > 0.05)."
34539742
sparser
"In summary, using data from a large population-based sample, we found that BMI may associate with HIN1 methylation status of postmenopausal breast tumor tissue."
26005715
sparser
"HIN1 methylation heterogeneity is associated with tumor size and extra-thyroidal extension (all P < 0.01), no association are found between HIN1 methylation heterogeneity and gender, age, tumor location, TNM stage and lymph node metastasis (all P > 0.05)."
34539742
sparser
"We also found that detectable PAH-DNA adducts were associated with HIN1 methylation in tissue of cases and LINE-1 in blood of controls, although the confidence intervals included the null value."
26407953
sparser
"Our previous studies found that DAPK , p16 , MGMT , MLH1 , RARβ2 , HIN1 , TFPI-2 , DACH1 , and SOX17 were methylated in the precursor lesions of human esophageal epithelia [ xref , xref , xref , xref – xref ]."
27110300
sparser
"HIN1 heterogeneous methylation, tumor size and tumor location are associated with extra-thyroidal extension, independently ( P = 0.006, P = 0.004, P = 0.025, xref )."
34539742
sparser
"Certain genes methylated in precursor lesions of the esophagus demonstrate that DNA methylation may serve as esophageal cancer early detection marker, such as methylation of HIN1 , TFPI-2 , DACH1 , and SOX17."
27110300
sparser
"In particular as a special case with the GST approach ( xref ), HIN1, RASSF1A and TWIST methylation levels were significantly lower in basal-like subtype compared to luminal (p = 0.006, p < 0.0001 and p = 0.0006, respectively) or HER2 subtypes (p = 0.003, p = 0.048 and p = 0.009, respectively), whereas their methylation levels were found to be similar between luminal and HER2 subtypes (p > 0.999, p = 0.090 and p = >0.999, respectively)."
20505321
sparser
"Among these five genes, DACT2 methylation is associated with gender, age, and tumor size (all P < 0.05), HIN1 methylation is associated with tumor size ( P < 0.05) and extra-thyroidal extension ( P < 0.01), RASSF1A methylation is associated with lymph node metastasis ( P < 0.01)."
34539742
sparser
"Methylation of RASSF1A and HIN1 in the benign fibroadenoma and BCa tissues."
39993808
sparser
"Our observation of decreased mortality among very active women with APC or HIN1 methylation is counter to our a priori hypothesis of lowered risk of death among active women with unmethylated (active) tumor suppressor genes, although we did observe that in the highest RPA group, there was no statistical difference in the effect among APC methylated and unmethylated cases."
28222775
sparser
"Cumulative RASSF1A, TWIST1, and HIN1 gene methylation accurately distinguished ducts with cancerous versus benign lesions (100% sensitivity, 72% specificity, and area under the curve of 0.91 according to receiving operating characteristic analyses)."
19470737
sparser
"The results suggest that methylation of DACT2, HIN1, and RASSF1A increases the malignance of thyroid cancer."
34539742
sparser
"Methylation of HIN1 is linked to gene silencing, reduced expression, and loss of apoptosis [ xref ]."
28222775
sparser
"The multivariable analysis suggested that CDH1 methylation heterogeneity is associated with lymph node metastasis and HIN1 methylation heterogeneity is associated with extra-thyroidal extension."
34539742
sparser
"The results suggest that CDH1 and HIN1 methylation heterogeneity may increase tumor metastasis."
34539742
sparser
"Cases with detectable adducts were less likely to have a methylated HIN1 gene(ROR=0.66, 95%CI 0.42-1.05), although the confidence intervals included the null value and the interaction was not statistically significant (p ≥ 0.10)."
26407953
sparser
"McCullough et al. later published a study in 2017 showing that in physically active women, there were significant decreases in the promoter methylation of the BC-related genes APC, CCND2, HIN1, and TWIST1, showing a beneficial effect of PA on DNA methylation patterns [ xref ]."
39272925
sparser
"The high specificity of HIN1 methylation in discriminating patients with NPC from normal individuals indicates its role as a tumor marker for NPC."
21439244