IndraLab
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eidos
"RSK1 and 2 also promote the invasion and metastasis of cancer cells from different tumours such as breast , colon , kidney , stomach and prostate , through mechanisms including ( 1 ) inducing a FRA1 and c-jun-dependent transcriptional program related to epithelial-mesenchymal transition ( EMT ) ; ( 2 ) phosphorylating SH3P2 and blocking its anti-motility effects ; and ( 3 ) phosphorylating filamin A and suppressing the integrin activation through its increased binding activity [ 74 ] ."