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OTUB1 binds OTUB2, TRAF3, and TRAF6. 1 / 1

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"Coimmunoprecipitation analyses indicate that OTUB1 and OTUB2 associate with TRAF3 and TRAF6, negatively regulating antiviral responses by deubiquitinating their respective K63‐linked polyubiquitin chains. [ xref ] Because various components are involved in virus‐induced signaling, biochemical assays have demonstrated that OTUB1 and OTUB2 inhibit RIG‐I‐, MDA5‐, and MAVS‐mediated but not TBK1‐ and IRF3‐mediated signaling."

33511009

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IndraLab

Statements

OTUB1 binds OTUB2, TRAF3, and TRAF6. 1 / 1

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