IndraLab

Statements

JAK2 phosphorylates JAK2 on Y570. 8 / 8
1 2 4 | 1
hprd
No evidence text available
15143188
signor
"The jak2 jh2 domain functions as a negative regulator and is presumed to be a catalytically inactive pseudokinase, but the mechanism(s) for its inhibition of jak2 remains unknown. Here we show that jh2 is a dual-specificity protein kinase that phosphorylates two negative regulatory sites in jak2: ser523 and tyr570."
21841788
biopax:phosphositeplus
No evidence text available
hprd
No evidence text available
18491316
hprd
No evidence text available
15143187
signor
"JAK2 is autophosphorylated on tyrosines 221 and 1007. tyrosines 221 and 570 in JAK2 may serve as regulatory sites in JAK2, with phosphorylation of tyrosine 221 increasing kinase activity and phosphorylation of tyrosine 570 decreasing kinase activity"
15143187
hprd
No evidence text available
17389395
rlimsp
"Y570 lies within the JH2 inhibitory domain and is thought to be the most important phosphorylation site for downregulation of JAK2 activity [7], [8]. Biochemical studies show that autophosphorylation of Y570 rapidly downregulates kinase activity."
27924280