IndraLab

Statements

HRAS increases the amount of CDKN1A. 7 / 8
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"However, in the p53 MEFs, the p21 level was not increased by HRas overexpression, which was ascribed to the loss of function of p53S, as we previously reported [14]."
36835200
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"V12 H-Ras expression caused dephosphorylation of pRb, a decrease in cyclin A, and an increase in p21 WAF1/CIP1 levels, an effect first reported with Raf in murine fibroblasts ( Sewing et al., 1997 ) a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Western blot results (XREF_SUPPLEMENTARY) show that knockdown of either HRAS or KRAS in HemSCs also decreased the protein levels of cyclin D1 and phosphorylation of RB1 but increased the protein levels of p21 and p53."
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"As shown in XREF_FIG, overexpression of constitutively activated HRAS or KRAS in HemSCs treated with siNGBR restored the protein levels of cyclin D1 and phosphorylation of RB1, p53, and p21 to the levels shown in control HemSCs transfected with siControl and empty vector."
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"Ostensibly, the presence of H-ras alone raises p21 expression over MCF-7 cells with no added H-ras."
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"In addition, expression levels of p53 and p21 WAF1 and CIP1 were increased by H-RAS V12 transfection."
32264658
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"In addition, expression levels of p53 and p21 WAF1 and CIP1 were increased by H-RAS V12 transfection."
32264658