IndraLab

Statements

UCHL5 deubiquitinates NLRP3. 5 / 5
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"Moreover, UCHL5 overexpression enhanced protein stability by deubiquitinating NLRP3."
37044315
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"At last, UCHL5 inhibition enhanced osteoblast differentiation by promoting NLRP3 ubiquitination and degradation."
36778113
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"Deubiquitination of NLRP3 by UCHL5 is required for inflammasome activation."
34431717
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"Rv1579c, secreted from MTB H37Rv RD3, interacts with the receptor for activated C kinase 1 (RACK1) via its amino acid Y80 at the C-terminus, then recruits ubiquitin C-terminal hydrolase L5 (UCHL5) to deubiquitinate NLRP3, and finally activate the NLRP3 inflammasome [XREF_BIBR]."
33503864
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"Deubiquitination and Activation of the NLRP3 Inflammasome by UCHL5 in HCV-Infected Cells."
34431717