IndraLab

Statements

UCHL5 deubiquitinates NLRP3. 12 / 12
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"UCHL5 inhibition enhances osteoblast differentiation by promoting NLRP3 ubiquitination and degradation."
36778113
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"These data suggest that UCHL5 inhibition enhances osteoblast differentiation by promoting NLRP3 ubiquitination and degradation."
36778113
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"A very recent study showed that de-ubiquitination of NLRP3 by UCHL5 plays an important role in the assembly and activation of inflammasome in HCV-infected hepatocytes 22."
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"Notably, it was previously reported that UCHL5 could deubiquitinate and activate the NLRP3 inflammasome in hepatitis C virus-infected cells and mycobacterium tuberculosis-infected macrophage [ 20 , 21[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
37044315
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"A recent study has demonstrated that Uchl5 can deubiquitinate and activate NLRP3 in HCV-infected cells, leading to IL-1β maturation and secretion (48)."
35872903
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"In the present research, our results revealed that UCHL5 enhanced protein stability by deubiquitinating NLRP3 protein."
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"Deubiquitination and Activation of the NLRP3 Inflammasome by UCHL5 in HCV-Infected Cells."
34431717
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"Rv1579c, secreted from MTB H37Rv RD3, interacts with the receptor for activated C kinase 1 (RACK1) via its amino acid Y80 at the C-terminus, then recruits ubiquitin C-terminal hydrolase L5 (UCHL5) to deubiquitinate NLRP3, and finally activate the NLRP3 inflammasome [XREF_BIBR]."
33503864
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"After HCV infection, Recombinant Ubiquitin Carboxyl Terminal Hydrolase (UCHL5) mediates the de-ubiquitination of NLRP3 (Wang W. et al., 2020), while the stimulator of interferon genes (STING), which functions as an NLRP3 activator, interacts with NLRP3 and then inhibits the ubiquitination of NLRP3 (Siu et al., 2019)."
37608944
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"Deubiquitination of NLRP3 by UCHL5 is required for inflammasome activation."
34431717
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"At last, UCHL5 inhibition enhanced osteoblast differentiation by promoting NLRP3 ubiquitination and degradation."
36778113
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"At last, UCHL5 inhibition enhances osteoblastic differentiation by promoting NLRP3 ubiquitination and degradation."
36778113