IndraLab

Statements

SMO binds UCHL5. 8 / 8
| 3 5
sparser
"Interestingly, Hh enchances the interaction between Uchl5 and Smo [ xref ]."
31429406
sparser
"UCHL5 interacts with Smo to promote its deubiquitination and accumulation at the cell membrane, and the interaction between UCHL5 and Smo is enhanced by Hh [ xref ]."
| PMC
sparser
"The deubiquitinating enzymes UBPY/Usp8 and Uchl5 interact with the C-tail of Smo and inhibits its ubiquitination [ xref – xref ]."
31429406
reach
"We provide both genetic and biochemical evidence that UCHL5 interacts with and deubiquitinates Smo, increasing stability and promoting accumulation at the cell membrane."
28992318
sparser
"For example, UCH37’s binding to Smoothened (Smo) counteracts Smo ubiquitination and leads to the stabilization of the Smo protein and the activation of the Hedgehog signaling pathway [ xref ]."
32726943
reach
"Strikingly, we find that Hh enhances the interaction between UCHL5 and Smo, thereby stabilizing Smo."
28992318
sparser
"Strikingly, we find that Hh enhances the interaction between UCHL5 and Smo, thereby stabilizing Smo."
28992318
reach
"UCHL5 interacts with Smo to promote its deubiquitination and accumulation at the cell membrane, and the interaction between UCHL5 and Smo is enhanced by Hh [44]."
| PMC