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USP14 increases the amount of TARDBP. 3 / 3
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"The DUB USP14 suppresses turnover of Tau and TDP-43 in mouse embryonic fibroblasts (MEFs) by impairing the protea-some;"
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"In particular, overexpression of WT USP14 in mouse embryonic fibroblasts leads to increased TDP-43 levels."
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"However, similar to what we observed in the hippocampi (Figure 2), this genetic reduction of USP14 was not sufficient to decrease the levels of the TARDBP, PRNP, or MAPT proteins, as the steady-state levels of these proteins were similar in the cortical neurons cultured from the USP14-deficient mice and the wild type controls (Figure S3)."
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