IndraLab

Statements

CYLD inhibits BCL3. 10 / 12
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"Here, decreasing CYLD levels activated BCL3 accumulation followed by its import into the nucleus, probably mediated by an interaction between the polyubiquitin chains of BCL-3 and importins."
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"CYLD prevents nuclear accumulation of BCL-3 and hence reduces Cyclin D1 expression and proliferation of keratinocytes."
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"CYLD negatively regulates BCL3, preventing nuclear entry where it forms a dimer with p50 and p52, resulting in transcription of genes involved in proliferation including cyclin D1."
21552290
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"CYLD, but not C/S-CYLD, abrogated BCL-3 binding of IL-10 promoter, confirming the important role of CYLD in the regulation of BCL-3."
19124656
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"Furthermore, siRNA against Snail1, which up-regulated CYLD expression (XREF_FIG), reduced nuclear BCL-3 levels, confirming that reexpression of CYLD blocks nuclear translocation of BCL-3 in melanoma (XREF_FIG)."
19124656
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"CYLD inhibits Bcl3 by antagonizing the K63-linked polyubiquitination of Bcl3 thus preventing its nuclear translocation."
22435550
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"In addition, CYLD negatively regulates the antiapoptotic molecule BCL-3, and Cyld −/− mice are more susceptible to chemically induced tumors ( Massoumi et al., 2006 )."
17723213
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"It was observed in malignant melanoma that loss of CYLD also induces nuclear accumulation of BCL-3 and NF-kappaB activation, with the consequence of induced N-cadherin (migration) and cyclin D1 (proliferation) activity."
29344161
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"Interestingly, the ubiquitin ligase CYLD, which negatively regulates bcl3 nuclear localization, was increased 2.7-fold in the RNA-Seq analysis (XREF_SUPPLEMENTARY)."
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"CYLD inhibits Bcl3 by antagonizing the K63 linked polyubiquitination of Bcl3 thus preventing its nuclear translocation."
22435550