IndraLab

Statements

CYLD inhibits BCL3. 10 / 11
1 | 8 1
reach
"Interestingly, the ubiquitin ligase CYLD, which negatively regulates bcl3 nuclear localization, was increased 2.7-fold in the RNA-Seq analysis (XREF_SUPPLEMENTARY)."
25873381
sparser
"CYLD inhibits Bcl3 by antagonizing the K63-linked polyubiquitination of Bcl3 thus preventing its nuclear translocation."
22435550
signor
"Cyld binds and deubiquitinates bcl-3in cyld+/+ keratinocytes, tpa or uv light triggers the translocation of cyld from the cytoplasm to the perinuclear region, where cyld binds and deubiquitinates bcl-3, thereby preventing nuclear accumulation of bcl-3 and p50/bcl-3- or p52/bcl-3-dependent proliferation."
16713561
reach
"CYLD negatively regulates BCL3, preventing nuclear entry where it forms a dimer with p50 and p52, resulting in transcription of genes involved in proliferation including cyclin D1."
21552290
reach
"CYLD prevents nuclear accumulation of BCL-3 and hence reduces Cyclin D1 expression and proliferation of keratinocytes."
19124656
reach
"CYLD, but not C/S-CYLD, abrogated BCL-3 binding of IL-10 promoter, confirming the important role of CYLD in the regulation of BCL-3."
19124656
reach
"Furthermore, siRNA against Snail1, which up-regulated CYLD expression (XREF_FIG), reduced nuclear BCL-3 levels, confirming that reexpression of CYLD blocks nuclear translocation of BCL-3 in melanoma (XREF_FIG)."
19124656
reach
"Here, decreasing CYLD levels activated BCL3 accumulation followed by its import into the nucleus, probably mediated by an interaction between the polyubiquitin chains of BCL-3 and importins."
26652480
reach
"It was observed in malignant melanoma that loss of CYLD also induces nuclear accumulation of BCL-3 and NF-kappaB activation, with the consequence of induced N-cadherin (migration) and cyclin D1 (proliferation) activity."
29344161
reach
"CYLD inhibits Bcl3 by antagonizing the K63 linked polyubiquitination of Bcl3 thus preventing its nuclear translocation."
22435550