IndraLab

Statements

USP17L2 activates BRD4. 7 / 7
| 7
reach
"We demonstrated that knockdown of endogenous DUB3 by two independent shRNAs largely decreased BRD4 protein and that these effects were reversed by restored expression of DUB3-WT and the phospho mimick[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30057199
reach
"Interestingly, a recent study shows that a proficient expression of deubiquitinase DUB3 in prostate cancer can promote BRD4 stabilization and resistance to BETi ."
34290255
reach
"We further showed that forced expression of DUB3 induced upregulation of BRD4 proteins in cultured cells and that elevation of DUB3 expression was correlated with a high level of BRD4 protein in a sub[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30057199
reach
"Treatment of DU145 cells with PD0332991 decreased BRD4 protein levels in a time dependent manner, and the effect of PD0332991 was completely impeded by the proteasome inhibitor MG132, arguing that CDK[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30057199
reach
"In contrast, knockdown of DUB3 by two independent shRNAs decreased the level of endogenous BRD4 proteins but had no overt effect on BRD4 mRNA expression in both PC-3 and DU145 cells."
30057199
reach
"DUB3 mediated BRD4 stabilization overcomes SPOP mediated degradation to confer BET inhibitor resistance."
30076149
reach
"Accordingly, overexpression of DUB3 increased the level of ectopically expressed full-length BRD4 protein in a dose dependent manner but had no effect on BRD4DeltaCTM mutant, BRD2 or BRD3 in PC-3 cell[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30057199