IndraLab

Statements

SLC5A3 binds KCNQ1. 5 / 5
| 1 4
sparser
"KCNQ1 physically interacts with SMIT1 in the choroid plexus, in tripartite complexes with KCNE2, and in vitro is thought to also form complexes with the structurally related myo -inositol transporter, SMIT2 xref , xref ."
32111967
sparser
"In vitro , SMIT1 can also form complexes with heterologously co-expressed KCNQ1, with or without KCNE2."
30959022
reach
"KCNQ1 physically interacts with SMIT1 in the choroid plexus, in tripartite complexes with KCNE2, and in vitro is thought to also form complexes with the structurally related myo-inositol transporter, SMIT2 XREF_BIBR, XREF_BIBR."
32111967
sparser
"Thus, SMIT1 co-expression, in the absence of extracellular myo -inositol or other SMIT1 substrates, changes ion selectivity, voltage-dependence and pharmacology of KCNQ1 in a KCNE1-dependent manner, consistent with a model in which SMIT1 physically interacts with the KCNQ1 pore or close enough to it to alter its fundamental attributes."
28718502
sparser
"SMIT1 also forms complexes with KCNQ1 when the two are heterologously co-expressed, and KCNE2 is not required for KCNQ1-SMIT1 complex assembly."
27789743