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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

TGFBR1 increases the amount of SMAD2. 1 / 1

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"Immediate early target genes of TGFbeta-Smad signalling include the inhibitory Smads, such as Smad7, which accumulate upon signalling and negatively regulate the pathway at the level of TbetaRI degradation, Smad2 and Smad3 phosphorylation by TbetaRI and at the level of chromatin bound Smad complexes, which are transcriptionally blocked by Smad7."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...