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EHMT1 methylates TP53 on K373. 13 / 13
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"Other study provides evidence that the G9a-GLP complex methylates p53 protein on Lys 373 residue and inactivates the growth suppression function of p53 in breast and lung cancer cells [ xref ]."
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"In addition to methylating histone substrates, XREF_BIBR, XREF_BIBR, XREF_BIBR G9a and GLP dimethylate K373 of the tumor suppressor p53."
21780790
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"Furthermore, GLP also methylates P53 directly on lysine 373 resulting in the inhibition of P53 activity (XREF_TABLE)."
24148750
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"G9a and GLP methylate p53 at lysine 373."
27580749
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"XREF_BIBR, XREF_BIBR - XREF_BIBR The di methylation of p53 K373 by G9a and GLP (also known as KMT1D or EHMT1), a closely related methyltransferase that shares 80% sequence identity with G9a in their respective SET domains and forms a heterodimer with G9a, results in the inactivation of p53, whose loss of function is implicated in over 50% of cancers."
21780790
sparser
"Other study provides evidence that the G9a-GLP complex methylates p53 protein on Lys 373 residue and inactivates the growth suppression function of p53 in breast and lung cancer cells [ xref ]."
25027955
reach
"Other study provides evidence that the G9a and GLP complex methylates p53 protein on Lys 373 residue and inactivates the growth suppression function of p53 in breast and lung cancer cells [XREF_BIBR]."
25027955
sparser
"Furthermore, GLP also methylates P53 directly on lysine 373 resulting in the inhibition of P53 activity ( xref )."
24148750
sparser
"G9a and GLP methylate p53 at lysine 373 ( xref )."
27580749
sparser
"Recently, Huang and colleagues have reported that, in addition to acetylation and ubiquitylation, K373 of p53 can also be methylated by two homologous histone methyl- transferases, G9a and Glp [ xref ]."
24298606
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"In addition to catalyzing mono- and dimethylation of H3K9, both G9a and GLP dimethylate Lys373 of the tumor suppressor p53, inactivating p53 's transcriptional activity 8."
21743462
sparser
"Furthermore, GLP also methylates P53 directly on lysine 373 resulting in the inhibition of P53 activity ( xref )."
24148750
reach
"Recently, Huang and colleagues have reported that, in addition to acetylation and ubiquitylation, K373 of p53 can also be methylated by two homologous histone methyl- transferases, G9a and Glp [XREF_BIBR]."
24298606