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OTUB2 inhibits TP53BP1. 3 / 3
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"Thus, the RNF8-RNF168 axis primarily suppresses HR and promotes non-HR-type DSB repair, e.g. NHEJ, and OTUB2 enables the initiation of HR by suppressing the excessive accumulation of 53BP1 and RAP80 in an early phase of the DDR."
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"Taking these findings together, we propose a model whereby OTUB2 inhibits excessive DSB-end protection and allows the initiation of HR by properly regulating the accumulation of RAP80 and 53BP1 at DSB[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"OTUB2 enables the initiation of HR by suppressing the excessive accumulation of 53BP1 and RAP80 in an early phase of the DDR [XREF_BIBR, XREF_BIBR]."
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