IndraLab

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"In the present study, our data showed that elevated CARP expression led to significantly increased apoptosis and decreased proliferation in BGC-823 cells, which suggested that CARP partly inhibits tumor progression via precise regulation of the balance of the cell growth and death."
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"Full length CARP cDNA induced weakly apoptosis in the absence of additional apoptotic signals (Figs. 5B and 6C); however, the deleted-CARP had no apoptotic activity, suggesting that intact CARD domain[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"We therefore examined whether cellular CARP is able to induce apoptosis when over-expressed in human cells."
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"Studies on the biological function of CARP have proved that overexpression of CARP could significantly promote apoptosis in lung carcinoma A549 and human embryonic kidney HEK293s cells, and inhibit cell proliferation in lung carcinoma A549 and PG, melanoma WM451, prostate cancer PC-3 and PC-3M, liver cancer H7402, and bladder cancer BIU87 cells XREF_BIBR, suggesting that CARP is a pro apoptotic protein and has potential anti-tumor effects."
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"To determine whether over-expression of CARP alone can induce cell apoptosis, A549 cells and HEK293S cells were stably transfected with control plasmid or plasmids carrying CARP or antisense-CARP, res[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Similar results were observed by MTT assay.Since over-expression of CARP induces weak apoptosis, we tested if over-expression of CARP can inhibit tumor cell line growth."
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"To determine if CARP induced apoptosis and inhibition of cell growth requires intact CARD, HEK293S cells, ECV304 cells, and A549 cells were stably transfected with CARP, CARP-MYC, deleted-CARP, antise[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The ectopic expression of CARP in H9c2 cells increased the resistance to hypoxia induced apoptosis."
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"XREF_FIG shows stable transfection of CARP induced cell apoptosis."
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