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Statements

CHEBI:16236 activates KCNMA1. 4 / 4
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"Ethanol-induced BK channel activation has been proposed as a mechanism for the neuroprotective effect of ethanol preconditioning against post-ischemic neuronal injury in mice (Wang et al., xref )."
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"To investigate whether ACA specifically modulated EtOH-induced BK channel activation or, rather, ACA modulatory action extended to other BK channel activators, we tested the effect of internal ACA on Hypo-induced BK channel activation in outside-out recordings."
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"The inhibitory impact of ACA on EtOH-induced BK channel activation did not change single channel conductance which indicates that ACA does not interfere with potassium ions passing through the channel, neither does EtOH affect this ion passage (Brodie et al., xref ; Treistman and Martin, xref )."
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"Ethanol-induced slo1 channel activation is also controlled by phosphorylation/dephosphorylation processes."
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