IndraLab

Statements

FN1 binds SDC4. 161 / 164
2 | 47 112
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"In tetrapods (amphibians, reptiles, birds and mammals) there are 4 tenascin genes: tenascin-C, tenascin-R, tenascin-W and tenascin-X ( xref ). xref Tenascin-C is the original “tenascin” that was first described independently in the myotendinous junctions and brains of the chicken Gallus gallus xref as well as in human glioblastoma-derived cells. xref The best studied of the tenascins, tenascin-C is expressed by motile cells such as the neural crest, at sites of connective tissue differentiation and in the adult in numerous stem cell niches; it also reappears during inflammation, at the margins of healing wounds and in the stroma of solid tumors. xref Tenascin-C from G. gallus binds to α9β1 integrins via the isoleucine-aspartic acid-glycine (IDG) motif found in the B-C loop of its third FNIII domain xref and to αVβ3 integrins via an RGD motif in the F-G loop of the same FNIII domain. xref Tenascin-C can also bind to fibronectin and prevent syndecan-4-fibronectin interactions, which in turn influences fibronectin signaling through integrins. xref Tenascin-C knockout mice have profound behavioral abnormalities and other phenotypes that are primarily associated with aberrant stem cell migration, proliferation and differentiation. xref Tenascin-R, the second tenascin to be discovered, is restricted in its expression to the nervous system xref and tenascin-R knockout mice also display abnormal behavior. xref Tenascin-W is often co-expressed with tenascin-C both in development and in stem cell niches. xref Murine tenascin-W has an RGD motif in the F-G loop of the second FNIII domain that appears to act as an α8β1 integrin-binding site. xref It and the tenascin-W of other species have the related lysine-glycine-aspartic acid (KGD) motif in the F-G loop of one or more FNIII domains, and synthetic peptides that contain this motif and neighboring conserved sequences promote cell proliferation. xref Tenascin-W knockout mice have not been analyzed."
25482621
sparser
"Igf1‐Igf1r, Fn1‐Cd44, Fn1‐Sdc4, Grn‐Sort1, and Tnfsf12‐Tnfrsf12a pairs were found between EAMs and fibroblasts (Figure  xref )."
39119903
reach
"For instance, direct interaction between TNC and fibronectin (FN) results in anti-adhesion by interfering in FN binding with syndecan-4 [32]."
36765641
sparser
"In the CA_HPV stage, SPP1_mac showed enhanced interactions with epithelial tumor cells via several ligand-receptor pairs, especially FN1-SDC1 and FN1-SDC4, indicating a potential role in promoting tumor progression."
40437003
sparser
"We identified 2 significant L-R pairs (Fn1-Sdc4 and Fn1-Cd44), mediating robust outgoing signals from monocytes/macrophages exhibited to osteoblasts, endothelial cells, mesenchymal stem cells, erythroid cells, and skeletal muscle cells, in the THBS signaling pathway (Supplemental Fig. 4C-D, Supplemental Fig. 5)."
40585205
sparser
"Notably, SDC-4’s function is spatially regulated: while it promotes matrix contraction at the wound center, its interaction with tenascin-C at the wound margins modulates fibronectin–SDC-4 binding, thereby preventing excessive contraction [ xref ]."
41226609
sparser
"Syndecan-4 (Syn-4) binds fibronectin and together with integrins stabilizes FA sites xref ."
26952325
sparser
"We found that Syndecan-4 (Sdc4) and Frizzled-7 (Fzd7) form a co-receptor complex in satellite cells and that binding of the ECM glycoprotein Fibronectin (FN) to Sdc4 stimulates the ability of Wnt7a to induce the symmetric expansion of satellite stem cells."
23290138
sparser
"There were some signaling pathways in the crosstalk between immune cells and fibroblasts, mainly including CSF (CSF1-CSF1R), TGFβ (TGFβ1-TGFβR1/2, TGFβ1-ACVR1/TGFβR1), FN1 (FN1-SDC4, FN1-CD44, FN1-ITGα4/ITGβ1) (Fig.  xref A, B; Fig. S5A-D; Fig. S6A-D)."
40380229
sparser
"Adhesins such as TSA56, ScaA, and ScaC xref – xref bind to host cell fibronectin and syndecan-4; these proteins then interact with integrin α5ß1, leading to activation of intracellular signaling that culminates in actin remodeling and clathrin-mediated endocytosis xref – xref ."
35739103
sparser
"Within the FN1 pathway, Fn1-Cd44 , Fn1-Sdc1 , and Fn1-Sdc4 mediated intercellular communication among cancer cells, with Fn1-Cd44 being the most potent ligand–receptor pair ( xref )."
40723284
sparser
"Disruption of interactions between syndecan-4 and fibronectin by the extracellular matrix molecule tenascin-C decreases focal adhesions on tumour cells leading to increased tumour cell proliferation [ xref ]."
21155971
sparser
"We used PLA to assess the binding of FN to Sdc4 in satellite cells, and similarly detected a strong signal in satellite cells on cultured myofibers ( xref )."
23290138
sparser
"The interaction of syndecan-4 with the HepII domain of fibronectin induces the oligomerization of the extracellular domain of syndecan-4, which in turn regulates the interaction of the cytoplasmic dom[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22504297
sparser
"Therefore, we conclude that Sdc4 binds FN on activated satellite cells."
23290138
sparser
"For example, we identified a decrease in interactions such as PTN-SDC4, PTN-PRPRZ1, and FN1-SDC4 between the communication of endothelial cells and ast_cluster1, as well as between cells with O/A markers and ast_cluster1 in AD samples compared to the control group ( xref )."
38502590
sparser
"In comparison to control samples, there is a decrease in interactions such as PTN-SDC4 and FN1-SDC4 between endothelial cells and ast_cluster1, as well as between cells with O/A markers and ast_cluster1 in AD samples."
38502590
sparser
"Furthermore, FN1 interacts with SDC4, an ECM protein that was decreased in abundance, and with the enzymes CP and CTSD, both increased in abundance in the T1D dataset."
28819457
sparser
"For example, it has been reported that TN-C may inhibit fibronectin initiating signaling by interfering fibronectin-syndecan 4 binding."
15972953
sparser
"For example, FN1-SDC4 signaling from Macros to AECs, C3-CD81 signaling from AECs to Macros, SFTPA1-TLR2 signaling from AECs to Monos, andB2 M -HLA-Fsignaling from Macros to Monos exhibited clearly stronger activities than other L-R pairs; the spatial distributions of signaling scores for these L-R pairs are presented in xref ."
40262896
sparser
"Following Sdc4 binding to FN in the extracellular matrix, the Sdc4 cytoplasmic domain binds phosphatidylinositol 4,5-bisphosphate, which stimulates PKCα activation, leading to the activation of small GTPases and assembly of focal adhesions (Oh et al., 1997; Saoncella et al., 1999; Couchman, 2003; Lim et al., 2003; Dovas et al., 2006)."
23290138
sparser
"Furthermore, the width of the energy barrier probed in this work for the SDC4 interaction with fibronectin is only ∼10% larger (and falls within the range of associated errors) than the width of 3.1 ± 0.1 Å reported for heparin ( xref )."
31337547
reach
"Since tenascin-C competed with syndecan-4 binding to fibronectin, it is possible that syndecan-4 is exclusively available as a coreceptor for growth factor receptors in the presence of tenascin-C."
19838819
reach
"In addition, TNC binds to FNIII13, blocking syndecan-4 binding to FN (Huang et al., 2001), which could contribute to the described changes in matrix patterning and may alter growth factor/chemokine sequestration and presentation (Radwanska et al., 2017)."
38660622
sparser
"In normal glucose conditions, small TN-C isoforms bind to FN and are incorporated into the matrix where they can limit the degree of FN matrix assembly in the glomerulus by controlling FN-syndecan-4 interactions, cell signaling, and contractility."
33543041
reach
"Additionally, in fibroblasts, the binding of Syndecan-4 to fibronectin allows the association of Syndecan-4 with protein kinase C-alpha (PKCalpha), which activates RhoG and triggers endocytosis of bet[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27235833
sparser
"Analysis of outgoing FN1, THBS, and SPP signaling from Mono&Maph to vascular cells revealed several ligand-receptor pairs with high communication probabilities, including Fn1-Sdc4 and Fn1- (Itga5 + Itgb1), Thbs1-Sdc4, and Spp1- (Itga5 + Itgb1) respectively (Fig.  xref )."
36721040
reach
"Fibronectin binds to a variety of extracellular and cell surface molecules, including integrins α5β1 and α4β1 and the HSPG coreceptor syndecan 4, and regulates cell adhesion, spreading, migration, gro[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
19138685
sparser
"This appears to be mediated by tenascin-C inhibiting interactions between syndecan-4 and fibronectin [19,20] , which in turn inhibits the recruitment of syndecan-4 to the focal adhesion complex."
19162090
sparser
"A syndecan-4-dependent interaction of cells with fibronectin regulates PCP components in the chordamesoderm xref , xref ."
24355988
sparser
"Comparison of the dissociation rate extracted for the SDC4-fibronectin interaction in this study reveals a 12-fold increase when compared with that reported for the heparin-fibronectin ( xref ), suggesting a weaker interaction between fibronectin and SDC4 than heparin."
31337547
sparser
"Furthermore, Wnt signaling, which dictates the fate of satellite cells by controlling their expansion, is highly dependent on the binding of the ECM glycoprotein fibronectin to syndecan-4 [ xref ]."
25729564
sparser
"However, from our spatial co-expression analysis, the CDH1-CDH1 interaction is significant in 3 out of 4 samples’ pattern 13 regions, while FN1-SDC4 is significant in 1."
41551846
reach
"Interference of tenascin-C with syndecan-4 binding to fibronectin blocks cell adhesion and stimulates tumor cell proliferation."
28874093
sparser
"A 17-key-gene LNM signature was identified, wherein the hub gene FN1 dynamically regulates migration and colonization via the FN1-SDC4 axis and stromal interactions during metastasis, which was validated by spatial transcriptomics."
41421038
sparser
"Because the Link module of TSG-6 binds avidly to glycosaminoglycans (e.g., heparan sulfate ( Mahoney et al., 2005 )), TSG-6 may facilitate FN fibrillogenesis either by directly engaging the glycosamin[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
18042364
sparser
"Bentzinger et al. showed that fibronectin could bind to Syndecan-4 to promote the expression of Wnt7a, thereby inducing the symmetrical division of satellite cells, and activated satellite cells can also reconstruct niche by autocrine fibronectin [ xref ]."
| PMC
sparser
"Specifically, syndecan-4 directly binds fibronectin to promote cell adhesions, thereby affecting cell migration, whereas the syndecan-4/PKCα/RhoA signaling axis promotes focal adhesion formation ( xref ; xref )."
33178691
reach
"In particular, syndecan-4 binds the major heparin binding site of fibronectin and acts coordinately with integrins such as alpha5beta1 in the assembly of focal adhesions (Woods et al. 1993; Couchman and Woods 1999; Longley et al. 1999; Saoncella et al. 1999)."
11257118
reach
"This inhibition of syndecan-4 binding to fibronectin results in increased growth of tumor cells ( Huang, Chiquet-Ehrismann, Moyano, Garcia-Pardo, & Orend, 2001 ) but suppresses proliferation of normal[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15094123
sparser
"It can be noted that both the width of the barrier and the dissociation rate extracted from the dynamic force spectra for the SDC4-fibronectin interaction are comparable to values reported for other protein-carbohydrate interactions ( xref , xref )."
31337547
sparser
"Previously, we had shown that cells are inhibited by TNC to spread on a combined FN/TNC substratum since TNC competed syndecan-4 binding to FN ( xref , xref )."
33790905
reach
"Later, Bass et al. (2007) observed that the binding of membrane protein Syndecan-4 with fibronectin suppressed Rac1 to produce highly persistent fibroblast migration."
29366821
sparser
"Monocytes/macrophages were prominent senders, transmitting signals to osteoblasts and other cell types via the Fn1-Sdc4 and Fn1-Cd44 pairs."
40585205
sparser
"FN1‐SDC4 interactions between endothelial cells and astrocytes were associated with blood‐brain barrier dysfunction (Figure 3)."
41442221
reach
"Syndecan-4 binds FN, inducing the formation of focal adhesions and activation of Rho, Rac and protein kinase Calpha (PKCalpha), yet syndecan-4-depleted cells deposit FN."
24190885
sparser
"Ruiz and colleagues [ xref ] and Lange and colleagues [ xref ] have associated triggering of glioma cell migration with a simultaneous mechanism of competitive inhibition of syndecan-4 binding of fibronectin and signalling by lysophosphatidic acid and platelet-derived growth factor (reviewed in [ xref ])."
20678196
reach
"In focal adhesions, cadherin-11 co-localizes with beta1-integrin and paxillin and physically interacts with the fibronectin binding proteoglycan syndecan-4."
26952325
sparser
"In the OA group, HomC cells were predicted to interact with HTC, preHTC, EC, and other cell types primarily through ligand-receptor pairs such as FN1–CD44, FN1–SDC4, and COMP–SDC4."
41111909
reach
"Syndecan-4 (Syn-4) binds fibronectin and together with integrins stabilizes FA sites XREF_BIBR."
26952325
reach
"This blocks syndecan-4/fibronectin interactions and ultimately downregulates RhoA and focal adhesion kinase activity by preventing clustering of α5β1 integrins and the formation of focal adhesion comp[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26055518
reach
"We found that Syndecan-4 (Sdc4) and Frizzled-7 (Fzd7) form a co and receptor complex in satellite cells and that binding of the ECM glycoprotein Fibronectin (FN) to Sdc4 stimulates the ability of Wnt7a to induce the symmetric expansion of satellite stem cells."
23290138
reach
"As an example, in endothelial cells, binding of syndecan-4 to fibronectin cated substrate results in syndecan-4 co-clustering with integrin alpha5beta1 and the activation of Rac-1 through the intracellular scaffold protein synectin."
19921267
reach
"We used PLA to assess the binding of FN to Sdc4 in satellite cells, and similarly detected a strong signal in satellite cells on cultured myofibers (XREF_FIG)."
23290138
reach
"Therefore, we conclude that Sdc4 binds FN on activated satellite cells."
23290138
sparser
"Huang et al. ( xref ) found that TNC was able to bind to FNIII13 in the heparin-binding site II and interfere with cell binding to FN by syndecan-4, thereby leading to human glioma proliferation ( xref ) ."
36033448
sparser
"The possibility that these sulfated fucans could hinder FN interactions with syndecan-4, thus leading to cell rounding, deserves further investigation."
37289485
sparser
"The FN1 signaling pathway, which primarily includes FN1-SDC4 (ITGA5/ITGAV/ITGA3 + ITGB1), is unique in that among the tumor cell subtypes, only EC6 can emit this signal, which acts on all cells, with T cells serving solely as signal receivers."
40087780
reach
"Moreover, blocking of FN binding to Sdc4 with Tenascin-C (TEN) selectively impaired the ability of Wnt7a to stimulate the expansion of the Pax7 + / YFP - satellite stem cell pool on myofibers cultured for 42h (XREF_FIG) without any effect on Pax7 + / YFP + satellite myogenic cells (XREF_SUPPLEMENTARY)."
23290138
sparser
"TNC competes syndecan-4 binding to FN, thus blocking integrin α5β1-mediated cell adhesion and actin stress fiber formation ( xref ) which results in a pro-tumorigenic gene expression profile and repression of multiple cell adhesion associated genes ( xref )."
29259017
sparser
"Tenascin-C was reported to interfere with cell spreading by inhibiting binding of fibronectin to its co-receptor syndecan-4 [126] ."
19339214
sparser
"By projecting ligand–receptor pairs onto the contour plots, they identified FN1-SDC4, FN1-ITGA3, and LAMB3-ITGA2 as the top three pathways from tumor cells to AFCs to FCs [ xref ]."
40558562
reach
"Following Sdc4 binding to FN in the extracellular matrix, the Sdc4 cytoplasmic domain binds phosphatidylinositol 4,5-bisphosphate, which stimulates PKCalpha activation, leading to the activation of small GTPases and assembly of focal adhesions (Oh et al., 1997; Saoncella et al., 1999; Couchman, 2003; Lim et al., 2003; Dovas et al., 2006)."
23290138
reach
"Previously, we had shown that cells are inhibited by TNC to spread on a combined FN/TNC substratum since TNC competed syndecan-4 binding to FN."
33790905
sparser
"A recent study shows that the binding of fibronectin to syndecan-4 induces α5β1-integrin endocytosis in a dynamin- and caveolin-dependent manner [ xref ]."
22605996
sparser
"Syndecan-4 interacts with the Hep II domain of FN through heparin sulfate chains with specific properties xref , and activates protein kinase C-α signalling xref in the presence of inositol phospholipids (reviewed xref , xref )."
30237127
sparser
"Tenascin-c, an extracellular matrix protein, is highly expressed in most solid tumors and antagonizes the adhesion of tumor cells through competitive binding to the syndecan-4 binding site on fibronec[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12781370
signor
"Inferred from SIGNOR complex SIGNOR-C210"
sparser
"The SDC4-α5β1 integrin mediated cell adhesion to fibronectin reduces tumor cell proliferation, whilst the tenascin-C-mediated inhibition of SDC4-fibronectin interaction and consequently the impaired fibronectin-induced signaling enhances the proliferation of glioblastoma cells [ xref ]."
34282767
sparser
"Notably, CDH11 is the only cadherin shown to interact with the ECM, through its binding partner syndecan-4, which binds to fibronectin and links cell adhesion directly to matrix interactions. xref , xref The role of Piezo1 in mechanosensing has been well-established, with studies demonstrating its role in focal adhesion formation and cytoskeletal remodeling to regulate cellular responses to substrate mechanics. xref – xref Although both CDH11 and Piezo1 have been independently linked to promoting IL-6 signaling in fibrosis progression, their roles in pulmonary fibrosis have not been investigated. xref – xref In this context, the ability of CDH11 and Piezo1 to integrate both mechanical and biochemical cues highlights the need for well-controlled in vitro experimental systems that can recapitulate mechanical and biochemical properties of tissue to better understand the relationships driving diseases like IPF."
41000860
reach
"A recent study shows that the binding of fibronectin to syndecan-4 induces alpha5beta1-integrin endocytosis in a dynamin- and caveolin dependent manner [XREF_BIBR]."
22605996
sparser
"However, TN-C can bind to FN at a heparin binding motif located around the 13 th FNIII repeat, which leads to a competitive hindrance of syndecan-4 binding to FN."
35785162
reach
"Furthermore, FN1 interacts with SDC4, an ECM protein that was decreased in abundance, and with the enzymes CP and CTSD, both increased in abundance in the T1D dataset."
28819457
reach
"When pulsatile forces were applied to magnetic beads coated with a fragment of fibronectin that binds heparan sulfate chains on syndecan-4, or to beads coated with antibodies toward the core protein of syndecan-4, there was a reduction in bead displacement upon sustained force application, suggesting a mechanical stiffening response."
36693448
reach
"Bentzinger et al. showed that fibronectin could bind to Syndecan-4 to promote the expression of Wnt7a, thereby inducing the symmetrical division of satellite cells, and activated satellite cells can also reconstruct niche by autocrine fibronectin [XREF_BIBR]."
| PMC
sparser
"We found that Syndecan-4 (Sdc4) and Frizzled-7 (Fzd7) form a co-receptor complex in satellite cells and that binding of the glycoprotein Fibronectin (FN) to Sdc4 stimulates the ability of Wnt7a to induce the symmetric expansion of satellite stem cells."
26136409
sparser
"Proper FGF signaling in MuSCs requires the interaction with Sdc4, β1-Integrin and Fibronectin ( xref ) ( xref )."
39050890
sparser
"Mechanistically, the C-terminal region of tenascin-C recognizes the heparin-binding site in the 13th FNIII domain of fibronectin, thereby blocking the interaction of fibronectin with the cell surface proteoglycan syndecan-4 [ xref ]."
23313574
sparser
"In these tumors, TNC reduces cell spreading on FN interfering with FN binding to the integrin co-receptor syndecan-4, thus compromising focal contact and stress fiber formation xref ."
21747918
sparser
"In this system, FN binding to Syndecan 4 stimulates it to form a co-receptor with Frizzled 7 that supports downstream signaling via Wnt7a to increase satellite cell expansion within the niche [ xref ]."
23849799
sparser
"Syndecan-4 connects 2 important signaling pathways (proteoglycans in cancer and ECM–receptors interactions) and it has been reported that blocking interactions between syndecan-4 and fibronectin decreases focal adhesions in cells, leading to increased cell proliferation in tumors."
33693651
sparser
"Syndecan-4 binds FN, inducing the formation of focal adhesions ( xref ; xref ) and activation of Rho, Rac and protein kinase Cα (PKCα) ( xref ; xref ), yet syndecan-4-depleted cells deposit FN ( xref )."
24190885
sparser
"It interferes with syndecan-4 binding to fibronectin and enhances proliferation of glioma and breast cancer cells xref ."
28469129
sparser
"We find that although Rac1, RhoA, RhoG and Arf6 are each regulated by the interaction between syndecan-4 and fibronectin, none of them is directly dependent on the others in the fibronectin-signaling pathway."
22790193
reach
"Disruption of interactions between syndecan-4 and fibronectin by the extracellular matrix molecule tenascin-C decreases focal adhesions on tumour cells leading to increased tumour cell proliferation [XREF_BIBR]."
21155971
reach
"Importantly, the binding of SDC4 to fibronectin is required by certain cell types for the activation of focal adhesion kinase (FAK), which stabilises focal adhesions by activating Rho and recruiting vinculin and paxillin."
26796346
sparser
"Syndecan-4 is a proteoglycan that spans the cell membrane and can bind to fibronectin [ xref ]."
33353083
reach
"This appears to be mediated by tenascin-C inhibiting interactions between syndecan-4 and fibronectin [19,20] , which in turn inhibits the recruitment of syndecan-4 to the focal adhesion complex."
19162090
reach
"This binding of syndecan-4 to FN and its association with the cytoskeleton may be relevant for syndecan-4-dependent dendritic cell motility."
17576238
sparser
"GPH treatment reduces the expression interaction strength between ligands and receptors (collagen-integrin and Fn1-Cd44 or Fn1-Sdc4) compared to sham, PH, and G. Altogether, this study presents a comprehensive single-cell resolution map of the molecular and cellular mechanisms by which GPH treatment impairs EMT in PDAC, identifying potential therapeutic targets within the fibronectin and collagen signaling axes."
40409452
sparser
"This repeat is required for fibronectin’s interaction with syndecan-4 to promote full cell spreading."
15094123
sparser
"This indicates that tenascin-C causes cell cycle arrest and cdk2 inactivation by interfering with fibronectin-syndecan-4 interactions."
12813465
sparser
"This inhibition of syndecan-4 binding to fibronectin results in increased growth of tumor cells ( Huang, Chiquet-Ehrismann, Moyano, Garcia-Pardo, & Orend, 2001 ) but suppresses proliferation of normal[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15094123
sparser
"The bubble plots of C0 and C5 cluster were also finished to describe the cell chat from epithelial C0 and C5 cluster. (Fig. xref D-E) We found that FN1-SDC4 ligand-receptor pathway was particularly remarkable when both C0 and C5 cluster was source cluster, revealing that it might play a potentially significant role in cellular communication."
41266683
sparser
"TN-C has been reported to compete with the binding site of fibronectin with syndecan-4, and this interaction with syndecan-4 partially abrogates the effects of this co-receptor, as well as attenuates the interaction of syndecan-4 with fibronectin, enhancing tumor cell malignancy."
35246056
sparser
"Similarly, tenascin-C can prevent cell adhesion to fibronectin substrates by blocking fibronectin-syndecan-4 binding ( xref ; xref ; xref )."
35693935
reach
"It interferes with syndecan-4 binding to fibronectin and enhances proliferation of glioma and breast cancer cells 57."
28469129
sparser
"Thus, Telci et al. [ xref ] have shown that interaction of fibronectin with a cell surface receptor Syndecan-4 can restore adhesion of fibroblast even if direct interaction between fibronectin and the cells is blocked."
26351461
sparser
"Syndecan-4 (Sdc4) and Fzd7 form a co-receptor complex in satellite cells and binding of the ECM glycoprotein FN to Sdc4 stimulates the ability of Wnt7a to induce the symmetric expansion of satellite stem cells."
26453496
sparser
"In addition, we also found some novel pairing relationships, such as LAMA4-CD44 and FN1-SDC4, and these results suggested that the C11 subpopulation played a great role in the development of PAAD."
37588985
sparser
"Additionally, in fibroblasts, the binding of Syndecan-4 to fibronectin allows the association of Syndecan-4 with protein kinase C-alpha (PKCα), which activates RhoG and triggers endocytosis of β integ[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27235833
sparser
"As an example, in endothelial cells, binding of syndecan-4 to fibronectin-cated substrate results in syndecan-4 co-clustering with integrin α5β1 and the activation of Rac-1 through the intracellular scaffold protein synectin (Tkachenko et al. xref ; Morgan et al. xref )."
19921267
reach
"Binding of the basal lamina protein fibronectin to Sdc4 stimulates the Wnt7a–Fzd7-induced symmetric division of satellite stem cells [ 71 ]."
37826946
sparser
"Additionally, we identified the presence of an FN1-SDC4 receptor-ligand pair in TCF19 -positive fibro NPCs (Fig.  xref G)."
40341079
reach
"Furthermore, binding of Syndecan4 to fibronectin facilitates Fz7 recruitment of Dsh to the plasma membrane and, subsequently, the activation of noncanonical Wnt signaling."
17130287
sparser
"16 L/R pairs: MIF-CD74, MIF-CD44, MDK-SDC2, MDK-SDC4, MDK-NCL, FN1-ITGA3, FN1-ITGB1, FN1-ITGAV, FN1-CD44, FN1-SDC4, APP-CD74, CADM1-CADM1, CD99-CD99, CDH1-CDH1, OCLN-OCLN and PTPRM-PTPRM ( xref ) were finally screened."
36523593
sparser
"The PCP protein, Disheveled, is translocated to the plasma membrane [ xref ] by a FN-dependent interaction of syndecan-4 with frizzled7 [ xref ]."
20739170
sparser
"Additionally, interactions involving Fn1-Sdc4, Fn1-Sdc1, and Fn1-Cd44 were frequently observed in M1-like (M1C1) with other cell types, whereas such interactions were rare in M2-like (M2C3) with other cell types (Supplementary Fig.  xref 4A-B)."
41068813
reach
"Both glypican and syndecan-4 bind the HepII domain of fibronectin similarly."
11544026
reach
"Interference of tenascin-C with syndecan-4 binding to fibronectin blocks cell adhesion and stimulates tumor cell proliferation."
23421390
reach
"Syndecan-4 binds tenascin-C and fibronectin, promoting wound healing in fibroblasts [129] ."
29079535
signor
"Sdc4 is a high affinity receptor for fibronectin (FN) […] Therefore, we conclude that Sdc4 binds FN on activated satellite cells."
23290138
sparser
"In both cases, tenascin-C acts by blocking the interaction of fibronectin with cell-surface syndecan-4 (Huang et al. xref ; Midwood et al. xref ) by binding directly to FNIII13 in the HepII domain of fibronectin (Huang et al. xref )."
19838819
sparser
"This binding of syndecan-4 to FN and its association with the cytoskeleton may be relevant for syndecan-4-dependent dendritic cell motility."
17576238
reach
"Rather, a domain of fibronectin that binds to syndecan-4 is also required for induction of these structures, and antibodies to syndecan-4 can substitute."
10916159
sparser
"Strong expression of SDC4 or FN was associated with significantly shorter overall survival, respectively. [corrected] Increased expression of SDC4 and FN may be underlying molecular alteration of osteosarcoma which accounts for more aggressive clinical behaviour."
22531343
sparser
"Furthermore, binding of Syndecan4 to fibronectin facilitates Fz7 recruitment of Dsh to the plasma membrane and, subsequently, the activation of noncanonical Wnt signaling ( xref ; xref )."
17130287
sparser
"Since tenascin-C competed with syndecan-4 binding to fibronectin, it is possible that syndecan-4 is exclusively available as a coreceptor for growth factor receptors in the presence of tenascin-C. In summary, in addition to its role in regulating the inflammatory response, there is strong evidence that tenascin-C may also play a direct role in the control of growth factor signaling that promotes ECM synthesis."
19838819
sparser
"The results indicated that macrophages acted as major signal senders, exhibiting strong interactions with other cell types through ligand-receptor pairs such as FN1–SDC4 and FN1–CD44 (Fig. xref F)."
41266404
reach
"Thus, the potential heparin antimetastatic activity can be based on interference either directly with the integrin-fibronectin binding or indirectly via competing for the proteoglycan binding of syndecan-4 to fibronectin."
22505933
sparser
"In a self-limiting feedback loop, the presence of TNC in the ECM inhibits its own expression by blocking syndecan-4 binding to Fn and down-regulating downstream RhoA/Rho-associated protein kinase (ROCK) signaling and subsequent TNC expression ( xref , xref , xref )."
36989370
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"XREF_BIBR TNC binding inhibits the interaction between fibronectin and syndecan-4 (SDC4), a transmembrane heparan sulfate proteoglycan that is required for cell spreading on fibronectin in synergy with integrin alpha5beta1."
25738825
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"The PCP protein, Disheveled, is translocated to the plasma membrane [XREF_BIBR] by a FN dependent interaction of syndecan-4 with frizzled7 [XREF_BIBR]."
20739170
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"Syndecan-4 interaction with TG2-FN complex was suggested to lead to β1 integrins activation via PKCα, with subsequent integrin mediated activation of the FAK downstream signalling cascade in RGD-independent cell adhesion [ xref ]."
30621228
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"Syndecan-4 glycosaminoglycan chains bind the HepII domain of FN1 in the proximity of alpha5beta1 integrin binding domain, and is included into nascent adhesions, suggesting that it participates in cell-FN1 interaction [XREF_BIBR]."
33731188
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"We discovered key ligand–receptor interactions, including LAMB3–ITGA2, FN1–ITGA3 and FN1–SDC4, involved in the transition of PTC cells from FCs to AFCs and eventually to tumour cells."
38426403
sparser
"Binding of the basal lamina protein fibronectin to Sdc4 stimulates the Wnt7a–Fzd7-induced symmetric division of satellite stem cells [ 71 ]."
37826946
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"Among ECM proteins, fibulin-1 was reported to interact with fibronectin and inhibit cell migration by disrupting the association between fibronectin and syndecan-4, which played positive roles in cell migration XREF_BIBR."
27194945
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"In a self-limiting feedback loop, the presence of TNC in the ECM inhibits its own expression by blocking syndecan-4 binding to Fn and down-regulating downstream RhoA/Rho-associated protein kinase (ROCK) signaling and subsequent TNC expression (27, 70, 72)."
36989370
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"Ligand‒receptor pathway analysis revealed a decreasing intensity trend of the FN1–SDC4 and FN1–ITGA3 pathways along this trajectory (Figure xref )."
38426403
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"This was in part owing to interference with SDC4-mediated signaling critical for regulating cell polarity and migration, consistent with the importance of HS in SDC4-FN1 coordinated cell motility [ xref ]."
41614767
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"The top three ligand‒receptor pathways from tumour cells to AFCs to FCs were identified as FN1–SDC4, FN1–ITGA3 and LAMB3–ITGA2 (Figures xref and xref )."
38426403
sparser
"In light of the demonstrated ability of CRP to bind FN1 to potentiate an inflammatory phenotype in endothelial cells [ xref ], and the importance of HS-dependent SDC4-FN1 interactions on nascent fibril formation in the ECM [ xref ], the new observations that CRP may also regulate HS production suggest a potential additional activity in regulating cell adhesion and motility."
41614767
sparser
"Notably, high expression levels of FN1–SDC4, FN1–ITGA3 and LAMB3–ITGA2 were associated with a decreased relapse‐free survival fraction of PTC based on gene expression profile analysis from TCGA database (Figure xref )."
38426403
sparser
"This suggests that FN1–SDC4, FN1–ITGA3 and LAMB3–ITGA2 may function as potential prognostic biomarkers for PTC."
38426403
sparser
"In addition, TNC binds to FNIII13, blocking syndecan-4 binding to FN ( xref ), which could contribute to the described changes in matrix patterning and may alter growth factor/chemokine sequestration and presentation ( xref )."
38660622
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"We observed a diverse TME landscape in LUAD, characterized by a significant reduction in the interaction network strength between malignant cells and immune cells, especially the FN1–SDC4, FN1–CD44, HBEGF–ERBB4, EREG–ERBB4, and CADM1–CADM1 interactions."
41415280
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"Furthermore, our ContourPlot analysis model enabled the exploration of ligand‒receptor interactions within tumour cells, AFCs and FCs. xref We identified several enriched pathways, including FN1–ITGA3, LAMB3–ITGA2 and FN1–SDC4, along the trajectory from tumour to AFC to fully transformed cells."
38426403
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"Because the Link module of TSG-6 binds avidly to glycosaminoglycans (e.g., heparan sulfate (Mahoney et al., 2005)), TSG-6 may facilitate FN fibrillogenesis either by directly engaging the glycosaminog[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
18042364
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"Meanwhile, our investigation into intercellular interactions revealed significant findings, including the FN1-SDC4 receptor-ligand pair in NK cells and monocytes ( xref and xref )."
40370639
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"One mechanism by which TNC modulates cell adhesion dependent processes involves its direct interaction with FN, which leads to interference of FN binding to syndecan-4 12."
28986537
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"This study aimed to explore the effects of TNF-α on the formation of FN/ITGβ1/SYND4 complex and the relative mechanism in NP cells."
31111299
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"SDC4 interacts with fibronectin (FN), a crucial extracellular matrix protein, to regulate key signaling molecules including protein kinase C epsilon (PKCε), focal adhesion kinase (FAK), and ERK1/2."
40426865
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"We find that although Rac1, RhoA, RhoG and Arf6 are each regulated by the interaction between syndecan-4 and fibronectin, none of them is directly dependent on the others in the fibronectin signaling pathway."
22790193
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"Rather, a domain of fibronectin that binds to syndecan-4 is also required for induction of these structures, and antibodies to syndecan-4 can substitute."
10916159
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"Interference of tenascin-C with syndecan-4 binding to fibronectin blocks cell adhesion and stimulates tumor cell proliferation."
11731446
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"As a sensor to the ECM mechanical properties, syndecan-4 binds to fibronectin to activate a series of signals, including the MAPK pathways, leading to cell proliferation and migration [ xref ]."
| PMC
sparser
"Orend et al. [ xref ] demonstrated that TNC causes cdk2 inactivation and blocks cell cycle progression from G 1 phase to S phase of anchorage-dependent fibroblasts by interfering with fibronectin–syndecan-4 interactions."
32817625
sparser
"This SDC4-FN interaction mediates cell adhesion, mechanotransduction, and cytoskeletal remodeling, ultimately modulating the growth, morphology, and mechanical sensitivity of dorsal root ganglion (DRG) neurons [ xref ]."
40426865
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"Figure  xref F highlights the interaction between FN1 protein and its binding partners within the extracellular matrix, including FN1-SDC4, FN1-SDC1, FN1-CD44, and FN1-integrin subunits."
41091430
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"For instance, direct interaction between TNC and fibronectin (FN) results in anti-adhesion by interfering in FN binding with syndecan-4 [ xref ]."
36765641
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"Syndecan-4 also provides additional signalling for focal adhesion formation by binding directly to fibronectin itself primarily via the HepII domain (containing the fibronectin type-III repeats 12-14) in the C-terminal region."
22607334
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"Ligand–receptor analysis revealed that the primary interactions between POSTN + CAFs and tumor cells occurred through COL1A1-SDC4, COL1A2-SDC4, and FN1-SDC4 (Fig. xref G)."
41132815
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"The integrin α5β1 heterodimer ( xref ) and Sdc4 ( xref ; xref ) bind to distinct domains of fibronectin and are required for NC cell adhesion and migration."
27101845
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"Once again, cells were able to spread without PKCα engagement; however, for focal complexes to form, interaction of syndecan-4 with fibronectin to recruit PKCα-mediated Rac1 activation was required, as knock down or drug-mediated inhibition of this kinase failed to activate Rac1 and induce the maturation of focal complexes ( xref )."
24309511
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"Supplementary Fig. 3F demonstrates the extent of interaction between FN1 protein and its partners in the extracellular matrix, including FN1-SDC4, FN1-SDC1, FN1-CD44, and FN1-integrin subunits."
41091430
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"For example, recruitment of Dsh (a key intracellular PCP component) to the cell membrane is dependent on fibronectin–integrin and Sdc4–fibronectin interactions in Xenopus CE ( xref )."
34842271
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"For example, the focal adhesion component syndecan-4 interacts with the III(12-14) region of fibronectin (HepII domain) through its HS chains."
17130131
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"Fibronectin binding to the Syndecan4 and Frizzled complex disrupts the asymmetric self-renewal of MuSCs, thereby promoting Wnt7a mediated symmetrical muscle stem cell expansion 100."
26248268
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"Sdc4 is a major component of focal adhesions and interacts with fibronectin during cell-matrix adhesion and cell movement ( xref )."
38634469
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"Consistent with this, while fibronectin binds to syndecan 4 and modulates frizzled-mediated Wnt response to maintain SCs in their niche xref , laminin-α1 mediates its effect on SC self-renewal through integrin-α6β1."
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