IndraLab

Statements

BECN1 binds TRAF6 and USP14. 6 / 6
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"In this study, we demonstrated that USP14 and Beclin 1 competitively interacted with the CC domain of TRAF6."
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"These results demonstrate that USP14 and Beclin 1 interact with the CC domain of TRAF6 while TRAF6 and USP14 interacted with the CC domain of Beclin 1 as depicted in Figure xref F."
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"As depicted in Figure xref C, these results suggest that USP14 and Beclin 1 can competitively interact with the CC domain of TRAF6 and inhibit TRAF6-mediated ubiquitination of Beclin 1."
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"Interestingly, biochemical studies in the present study revealed that USP14 and Beclin 1 competitively interacted with the CC domain of TRAF6."
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"Taken together, these results suggest that USP14 and Beclin 1 can competitively interact with the CC domain of TRAF6 and inhibit TRAF6-mediated ubiquitination of Beclin 1, leading to decreased autophagy induction as depicted in Figure xref in Supplementary Material."
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"Based on these previous findings, we hypothesized that the suppression of Beclin 1 ubiquitination by USP14 might be critically associated with TRAF6-mediated ubiquitination in both autophagy and TLR4-mediated signaling."
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