IndraLab

Statements


| 6

sparser
"Taken together, our results demonstrated that Slug and Twist associate with Dub3 and are subject to Dub3-mediated de-ubiquitination, which contributes to their protein stabilization."

sparser
"Our current results demonstrated that Dub3 interacts with Slug and Twist and prevents Slug and Twist from degradation mediated by these E3 ligases."

sparser
"Dub3 interacts with Slug and Twist."

sparser
"In addition, DUB3 also interacts with SLUG and TWIST and prevents their degradation, thereby promoting migration, invasion, and cancer stem cell-like properties in breast cancer cells [ xref ]."

sparser
"Concurrently, we also performed endogenous Co-IP and confirmed the association of Dub3 with Slug and Twist in MDA-MB157 and SUM159 cells (Figure xref )."

sparser
"Of importance, Dub3 interacted with Slug and Twist and prevented them from degradation, thereby promoting migration, invasion, and cancer stem cell (CSC)-like properties of breast cancer cells."