IndraLab

Statements

UCHL1 deubiquitinates TP53. 6 / 6
1 | 1 4
reach
"However, while exploring the relationship between UCH-L1 and p53 ubiquitination, it is important to keep in mind that, despite hypotheses to the contrary [XREF_BIBR, XREF_BIBR], it is unlikely that UCH-L1 directly deubiquitinates or ubiquitinates p53 based on what is known about UCH-L1 structure and function [XREF_BIBR, XREF_BIBR]."
22811913
trips
"These results indicate that UCHL1 could deubiquitinate p53 and p14(ARF) and ubiquitinate MDM2 for p53 stabilization to promote p53 signaling, thus involved in nasopharyngeal carcinoma pathogenesis, whereas it is frequently silenced in this tumor."
20395212
ubibrowser
"These results indicate that UCHL1 could deubiquitinate p53 and p14(ARF)"
20395212
reach
"Our previous work demonstrated that UCHL1 could activate the p14ARF-p53 signaling pathway by deubiquitinating p53 and p14ARF as well as ubiquitinating MDM2, which might be through its two opposing enzyme activities, hydrolase and ligase, further resulting in its tumor suppressive role in NPC tumorigenesis XREF_BIBR, XREF_BIBR."
22279545
reach
"As P53 protein is regulated through ubiquitin dependent degradation in tumorigenesis, UCHL1 promotes p53 signaling by deubiquitinating p53 and p14 ARF and ubiquitinating MDM2 for further MDM2 degradation and p53 stabilization, thus involved in NPC pathogenesis as a functional TSG XREF_BIBR."
21439244
reach
"These results indicate that UCHL1 could deubiquitinate p53 and p14 (ARF) and ubiquitinate MDM2 for p53 stabilization to promote p53 signaling, thus involved in nasopharyngeal carcinoma pathogenesis, whereas it is frequently silenced in this tumor."
20395212